I think you have fallen prey to the only problem I had while on MTX and prednisone...yeast infections.
Is the discharge whitish? Does it have lumps in it, even if they are small, that still counts. Light spotting, you already said yes. Sometimes hurts to wipe after urination, or stings a little while urinating? If this sounds familiar, I would be willing to bet that you also take a prescription pain medicine. That pain med is keeping you from noticing what otherwise would be a totally miserable vaginal yeast infection. Don't bother with OTC treatment, it won't work, since this probably has been there for a while. Get a script for some yeast med, and cross your fingers that this won't be an ongoing issue.

Oh my gosh! I've been a member for less than 24 hours and already I'm learning something that will help me. Thanks so much for this post. I must be having a similar side effect. I had no idea that the MTX could cause such symptoms. I see my RA doc tomorrow and will mention it.

Omgoodness, the same has happen to me, but only while n Prednisone b4 i started the MTX. Now i know wht the prpblem is. I asked my RA Dr. abt it and the man didnt know what i was talkin abt, w.e...Now, i know y, thx for these post...thx so much.

Rheumy's don't usually consider yeast infections as a side effect. Yeast infections are simply much easier to get and go wild in a immune supressed person. It is the same thing with a cold. It is not a side effect, but can become the worst cold you've ever had, or devolop into something else, i.e. pneumonia.
I have nearly constant yeast infections, I really don't think they ever really clear up, just get better, then worse. I'm supposed to go to my OB_GYN soon so maybe we can come up with something that will work better.

In May I started spotting like clockwork 48 hours after I took MTX. I switched pills two weeks ago and [proverbially crossing my fingers] that seems to have done the trick.
However, I am on nearly the highest estrogen birth control you can take. After this I am out of options.
I see a new gynecologist next Monday.
Last month, I saw a new one after running through a gamut of tests with the nurse practitioner I see. And the jerk blew me off, nearly convinced me that the Ortho Cyclen I was taking was tri-phasic (depsite me arguing with him about it) and then "switched" me to another generic of the same freaking pill! ARGH!!!! So I wasted a co-pay on the office visit AND a rx copay!

I have had increased mucus discharge, without having a yeast infection. It stays for about four or five days, starting on Monday. I know for a fact that there is no yeast infection because I have done the swab and stained it . . . looking for it. It isn't bacterial vaginosis either.
I would recommend you have it checked out. Just to be safe.

Thank you everyone. I saw my gyn today who thinks it's related to the meds but wants me to get an ultrasound just to be sure. What a great support you all are. Hugs.

Ok, MOnday, I saw a new GYN.
After the one I saw in July told me that my Rx for Ortho-Cyclen was not mono-phasic (which it IS) and that was why I was spotting, didn't even look at my US report and prescribed a different generic of the same freaking pill!!!! ARGH!!! It's being investigated by the Ombudsman of the hospital system, but I digress.

So this doctor was recc my a good friend of mine who works in a field similar to what I am studying.

We immediately hit it off, I really think she's a good fit for me. She feels that I am correct in being concerned that the MTX is interfering with the efficacy of my birth control pills. Especially since, three weeks in on the higher dose pill and I am spotting again!!! WTH!
She said I have tried every course of alternative options that she reccommends, so she feels it is time for me to petition my insurance for a tubal ligation. That way, if the spotting DOES continue, at least I don't have to worry about pregnancy. I have to stay on the pill for treatment of PCOD. Which the doctor in July said, I would have to stay on the pill because once I had a tubal my insurance will not cover the pill. WHich is absolute BS because the pill is used to treat PCOD . . . .
So, I am scheduled to have s Saline Infused Sonography on the 4th of September to make sure that there is nothing abnormal regarding my uterine lining (also a prerequisite for having a tubal under these circumstances), like a polyp. And if there is a polyp, she said that they will remove that that the time of surgery.
I see the surgeon a week after the US, we tried to get them on the same day, but it isn't possible since it is so close. their schedules are booked. Ugh . . . but that is okay!
I will let you know how things procede . . . especially since I am not the only one having this.

The GYN agreed it would be highly unlikely that I consistently spot withing 48 hours of my MTX if there wasn't an interference with the pill by the MTX. She also said, before I could say it, preventing pregnancy is an absolute must on MTX! Duh! (direct at the @$$ I saw in July!!!)

I had a saline infusion sonogram today to ensure that I do not have any abnormalities that require a DNC and am happy to report that there was nothing to indicate that one was necessary.

The uterine lining was slightly abnormal, but no polyps, etc. My doctor was going to write a letter to the insurance company indicating that I need to have my tubes tied. I will then try to go off of the Pill and see if the intermittent bleeding goes away AND I don't have symptoms of PCOD . . . if the PCOD relapses, then I will go back on the pill to treat that.

I see the surgeon on Monday

I am diabetic and anytime a doctor writes me a RX for antibiotics, I hold out my hand waiting for the RX for Diflucan also. That's the only time I get a yeast infection is with an antibiotic and so we go ahead and treat me with Diflucan. I haven't gotten yeast infections with MTX or any medications other than antibiotics. I think diabetic women are prone to yeast infections but it takes the addition of antibiotics to bring one on in me. The OTC stuff doesn't work for me. It makes it worse. Diflucan pill is fast and efficient at knocking it out.

Well, I haven't had a yeast infection since the last time I was on antibiotics.

Diabetics are more prone to yeast infections due to a higher glucose level (even if it is just in the high end of "normal"). The fact that you don't get one without antibiotics is a good indicator of your level of diabetic control . . . :)

I always ask for the diflucan along with my rx. (and it is on Target's generic list)