Rheumatoid Arthritis Support Group

Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and...

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3ldsmama 02/20/2018

I have taken three methotrexate injections. I am nauseated for two days afterwards. Any suggestions? I haven’t been on it long enough to know if it is helping my symptoms so I don’t want to give up just yet. I started at 60 for two weeks and just bumped up to 80 per my doctor. Just can not shake the nausea. Eating not eating really doesn’t help. Nausea is worse when I stand up and walking around. I have thrown up a couple of times because it was so bad.

Kimhurts 02/20/2018

My nausea got better. I guess my body got used to it, but I still occasionally get nausea. I try ginger... anything ginger. Ginger ale, ginger snaps, ginger tea, candied ginger and for me, that works about 70% of the time. The other times I have a script for Phenergan, but it puts me to sleep, so if you try a script like this, you need to be prepared for your day to be over. Everyone doesn't react that way, but you might.

I hope you find something that works for you. Hang in there.

californialynn 02/20/2018

I guess it's been too long since I took the injectable.....

What does 60 and 80 equate to in terms of tablets [mg]?

In any case.....I was never nauseous on the injectable form.

Bellselles 02/27/2018

I've been on the injectable methotrexate for about 6 months, and used to get really bad nausea for a day or two after I took it. My doctor suggested doing the injections in my thighs rather than my stomach, and I rarely have problems anymore.

Hope this helps!

3ldsmama 02/27/2018

Thanks everyone’. I thought I was going crazy. I am putting them in my thigh already. I am eating before taking them but still no relief. Anymore suggestions I am looking for some relief. I believe the metho is helping my RA but not sure if it is worth the nausea. I have done 4 injections and still no let up on the nausea. Thanks again for your support. This site has helped me understand a lot of what is happening to my body.

californialynn 02/27/2018

YOu're talking about 60 or 80 units of injectable MTX, right? This would be equivalent to 15 or 20 mg pills.

Are you taking folic acid?

I would definitely use the thighs, which I always did.

I just find it strange that there's nausea since the way the MTX is metabolized is NOT through the stomach.

nonightshades2 02/27/2018

Nasty crap, but it does help. All suggestions above are correct with my experience, in the thigh, folic acid tab daily and ginger. Careful with the ginger because too much and you'll stop-up and be running to the drug store for a bottle of "thunder and lightning".

I have found that sugar and dairy make mine worse.

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