Rheumatoid Arthritis Support Group
Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and...

Not everyone has side effects. You can get nausea from either Plaquenil or Methotrexate. So there is no way of telling which is causing your significant other's side effects unless he's been off one or the other for a while and the side effect goes away.
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thank you :)
Plaquenil I have been on twice. It did not hurt my stomach, but it didn't work at all, in the slightest bit either time. Waste of a drug, I always say! Just my opinion.
thanks.