Rheumatoid Arthritis Support Group
Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and...
The first year is the hardest. It's about finding the best rheumatologist [it's like finding a lifelong partner], getting the right diagnosis, getting the right treatment, adapting to some lifestyle changes [in some cases].
Don't be alarmed about what you read about the meds. They're time honored and they work for the vast majority of patients.
Have questions? Ask away. We have a great group of people who will give you a whole spectrum of opinions.
You asked what to expect. Bear in mind that we're all different. Here's my experience:
MTX: I was started on small dose [5mg weekly] and it was upped over a period of weeks. about 2 months or so after starting I saw noticeable improvement.
Humira: I saw noticeable improvement in 3 weeks. I've had not one side effect from it.
I'm guessing you won't be on a high dose of MTX if the gameplan is to add the biologic. This is good that your doctor believes in aggressive treatment. [Back when I was diagnosed, we didn't have biologics.]
If my guess is right and you are maintained on about 7.5 mg of MTX while taking a biologic, you most likely won't experience any nausea. And remember - some people, even at higher doses, don't experience any nausea.
You might experience some lethargy......but my experience was that only in times of acute flares or in much higher doses of MTX did I experience fatigue. If you do, try to document how long after the MTX it comes and how long it lasts. If you work M-F you can probably take your MTX on a Friday so that it has no impact on your work. Again, at lower doses many people don't experience lethargy.
With respect to the biologic injections, if you'll be getting "pens" then it's super, super easy if you know how. We can walk you through it as the time draws closer. Very easy and no need to be apprehensive.
Count yourself lucky to have aggressive treatment.
The first thing I would say is "Don't be afraid of the meds!!" In fact, meds are your best friends! The sooner you get on the better, and you are fortunate to have gotten in early, and also gotten a rheumatologist who is treating you aggressively.
This disease can be debilitating, or if you get on the right combo of meds, it can cause minimal problems. It also sounds like you might have sero-negative RA, because it is affecting your hands so badly. You might want to ask about that, as well as other blood test results. I have found I like to monitor my blood tests, just to know where I am at.
Anyway, welcome to the group, if not RA!
15 mg starting seems a tad high, but it sounds like the rheumatologist is going for very aggressive treatment. That's good on one side of the coin, but it doesn't give the body much of a chance to adjust to the MTX.
http://www.rheumatology.org/I-Am-A/Patient-Caregiver/Treatments/Methotrexate-Rheumatrex-Trexall
Care to share what criteria/tests your doctor used to diagnose?
Just remember, the first year is the hardest. But I see that you're very conscientious about this and very invested in getting the facts, so my take on it is that you'll deal with the changes and make headway faster than most. Too many are often in denial and are biased against the drugs, making that first year horrible for them. If my hunch is right, you just want to get to the bottom of it, launch the treatment, and get on with life.
Great attitude.