Rheumatoid Arthritis Support Group
Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and...

It took a couple weeks to notice a slight difference and then some improvement after that, however, I recently began Humira because the MTX alone just wasn't cutting it and my rheumy likes to be aggressive. She was adamant about taking Folic Acid except on the days I take the MTX. I think you might want to ask your doc about that.
Good luck - hope you get good results and continue to tolerate it well!