The first month I had added fatigue...but also had nausea and vomiting. I never had the mouth ulcers, but I did get a couple of nose sores. Each week was a little better. Most people that work during the week take MTX on Fridays so they can rest/recover over the weekend.

Hi Lori57703

MTX brings the fatigue or it did for me. After about 3 weeks all the side effects for me were gone - never had it as bad as most, but the fatigue - wow

Hope you get better soon

Peace
Bluedogs2

Fatigue is the only side effect I've experienced from taking MTX. I've been on it this time since April of this year. I take my injection Thursday evenings. I'm usually tired on Fridays, but Saturdays really hit me hard.

Thank you all! I was planning on Fridays but got freaked out Wednesday and started earlyier than planned. Next week I will move it to Friday's for sure. I certainly cannot do this all the time! At least I know I am not crazy.

Got to say the fatigue gets to you after a while. I have-make that had-abounding energy, and now I feel like the molasses you refer to. I've been on mtx since Feb this year and I don't see the fatigue lifting anytime soon! I am lucky enough to be retired from work, but not at all ready to retire from life! My thoughts are with you. Trish

I dont think it is just the mtx. I think the disease itself, if active - or more active than usual - causes it as well. I always understood from this site that the injectable mtx had less side effects than pills. Given you are sleeping ok it isnt a sleep thing which sometimes is part of RA and its nighttime aggression.

I have been on mtx pills for some years and to answer your question I think my tiredness ebbs and flows in a downhill sort of way. I am tired more often now than I was seven years ago but I am a lot older and into those years tagged with Significant Side Effects.... You are heaps younger and so shouldnt be so tired. On the other hand you are a nurse!!! Not exactly an untaxing job...

I cant remember what else you do or take in terms of this disease but given it was your first injection maybe things will improve when your body adjusts. I wonder if it is worth trying those overnight liver herb pills - have the thistle herb which supposed to be good and sometimes clears my brain a bit when I am feeling blah. The ones I get dont interact with allopathic drugs negatively.

Whatever the ills of mtx I have had significant good periods while on it. I think it is failing me now (after four steady years - started, taken off, then re tried) but I recognise its value as well as its yukky-next-day downside.

I'm so sorry your not feeling well. My fatigue didn't go away yet and it's been almost a year. I'm thinking that side effect will stay with me lol. But the nausea and vomiting went away after 2-3 months. Hope this helps and hope you feel better

It did the exact same thing to me plus a few other things. It was like having narcolepsy. The 2 days following I would do nothing but sleep and have to take 2-3 naps the 3rd day. I took it for a month and had to change to something else. I couldn't function while taking it. What's odd is that fatigue is not listed anywhere in any list of side effects, but everyone I have to talked to or read seems to have it to one degree or another the day after taking it. I had never experienced fatigue even 1/10 of what I did after taking mtx. Hopefully they will subside to a manageable level soon, but if they don't there are other options. Good luck!!

Thank you, thank you everyone. I think it is getting better tonight. I did have to take a nap today and I had to work in alternating sessions of rest. My brain seems much more alert tonight.

I'm pretty sure it is the MTX that hit me so bad the last few days. I have had general fatigue for months but not like this. Anytime I move around too much (which is actually very little) all my muscles feel exhausted and shakey like I have done a major workout. My limbs feel very heavy.

Hopefully it will get better in time.