I take Cymbalta but it has not helped my RLS. My doctor prescribed it more for Fibro / nerve issues. I would suggest you make one change to medication at a time though and not go off all of those meds while starting a new one. You should double check with your doctor but if you start/stop all those at once and have any bad symptoms,. you won't know if it is from withdrawing offf the existing meds or starting the cymbalata. I know a lot of people whose pain has improved from Cymbalta so don't lose hope because it didn't work for me. It is probably worth a try. Good luck!

Thanks, its not really doing anything for my depression and its definitly not helping the RLS, so i will talk to my psychiatrist and see about switching. There's gotta be something out there that works, right?

You know Cymbalta helps my depression but there is a good benefit from my moods being better the pain does not hurt as much. My pain is a lot worse when my physical or mental hurts or is exasurbated.

I take 60mg of Cymbalta for my RLS and I also take Clonazepam 0.5mg three times a day for nerves and I find that my RLS and my anxiety is greatly improved. Hope you find what works best for you. Drinking tonic water also helps, it has an additive Quinine that is an active ingredient in RLS medications.

I was on Cymbalta for myofascial pain and post-herpetic neuralgia. All it did was make me sleepy. Regardless, a few individuals' experience with the medication should not influence your decision to try it. There are many people Cymbalta has helped.

It may not be a good idea, however, to make so many medicine changes at once - because then you will never know which change actually helped or worsened your condition. Most docs make one change at a time. Make sure your doc is on board with all these changes.

My current regimen for RLS is Lyrica and Requip XL. I also suffer from moderate to severe RLS. These meds have done wonders. I probably don't have to tell you that I too suffer from chronic intermittent depression, usually when I am having stints of chronic pain (surprise, surprise). I am currently not on any antidepressants. SSRIs (zoloft, prozac, etc.) are known for making RLS worse. I'm not sure if SNRIs (Cymbalta) do as well. By the way, never take benadryl to sleep if you have RLS. My neurologist is an expert in RLS. I am only forwarding the information.

I hope you feel better soon.

Thanks for the information. Mirapex helps a lot with my muscle aches, leg pain. I take it in the morning too. Awesome suggestion tonic water - thank you. I am buying it tomorrow. I would love to hear more what your neurologist said about RLS. I have heard about the Benadryl. I used to take it all the time at night too for rashes & feeling itchy all over.

I take Mirapex also. I didn't get the prescription filled and didn't take it for 3 days. On the third day, I didn't get any sleep because of my leg. I got the presc filled the next day and two days after I started taking it, my leg was back to normal and I was able to sleep again. I also take Cymbalta 120mgs at night along with Trazadone. I have no problem getting to sleep and no hangover effect in the AM. When I first started them, though, I did have that hangover effect in the AM for about a week.

Good luck and I hope you can get some relief soon.

Cymbalta has a better chance of worsening RLS than helping it. But as you have already noted, individual response may vary considerably.

I took cymbalta for depression and my RLS went into overdrive!

I researched and most SSRI anti-depressants are not recommended.

I would like to add a few things here. Besides Benedryl, most over the counter sleep meds also have Diphenhydramine in them, which will drive 99% of RLSer's crazy. It will exacerbate your symptoms to a point you thought they could never get to. I was on Cymbalta. It made me edgy, and
did nothing for my RLS either. One of my support groups is 1275 people, and not too many have had success with it for RLS. we always say, though, it is all trial and error until you hit on something that works.
I would like to make a comment on the Quinine. It is not an ingredient in RLS meds at all. It is good for leg cramps, like charlie horses, but not
RLS. This is pretty well documented. However whatever works; just saying that it is not in any RLS medication at all. Just clearing that up.
Lots of people get leg cramps and RLS mixed up, and they are two totallyy different things. In the end we have to find what works for us, and it is good to hear from as many people as we can. Not trying to argue with anyone here, but I have been researching RLS for 13 yrs. If there is amed with Qunine in it that is approved for RLS, I would be very interested in hearing about it.
I have tried the whole list of meds, and in the end it is my meds for chronic pain that also help with my RLS. Opiates are becoming more and more accepted treatment in hard to treat cases.
Good luck with the Cymbalta. I hope it helps you. let us know.
Oh, and for over tye counter sleep meds Unisom has 2 different formulas out now. One has the big bad diphenhydramine, and the other has Doxylamine Succinate as it's main ingredient, which does not seem to bither RLSer's.

I wanted to add that tricyclic anti-d's are also as bad as SSRI's for RLS for most. that would be meds like Elavil/amitriptylene. Personally, for me, that was my biggest RLS nightmare when the doc thought I should take it for migraine prevention. Not only did it not stop the migraines, but I have never had such bad RLS in my life. This is pretty universal also for MOST.
Always remember that there are exceptions.
http://www.rlshelp.org is a great web site to look up what this neurologist says about treatments for RLS. he is on the medical advisory board fro the RLS Foundation. You can read all about the good and bad meds on the treatment page.

I started taking cymbalta almost 4 weeks ago for depression and I was a bit nervous about the possibility of the RLS getting worse. One of the reported side effects is leg spasms so you can understand my concerns. However, apart from a bit of a 'flare up' of RLS in the first week it has actually improved RLS symptoms quite dramatically. I have virtually no problems in the evening with RLS now and am feeling so rested from being able to lie down and fall asleep without the jumpy legs.
Btw cymbalta is an SNRI but I don't know if that makes a big difference from the SSRIs, which are supposed to be unhelpful for RLS.

Hi --- I believe use of this antidepressant has caused me temporary
RLS. ( I have not been diagnosed ), but i am shaking my legs , they burn , they pull , they feel itchy and creepy crawly.

I have had leg problems with other antidepressants too
such as Prozac , Effexor , Lexapro , Paxil , and now the Cymbalta.

I need an antidepressant and have no luck thusfar with one that does not make my legs shake , move , and burn .