Has anyone ever noticed an increase in RLS after taking cymbalta? I take .25 requip for RLS and it was working fine. My iron was low and once they got that up I was only needing it just before bed with no problems during the day. Then my doctor put me on Cymbalta for fibromyalgia. At first I was taking only 30 mg and was okay with the RLS but still having pain from the FM. I'm really super sensitive to medications so they are careful to start small and work up in dosage. I usually need way less than most people. If I take dayquil or anything with a decongestant I get so tired I have to go to sleep. I got to 60 mg of cymbalta and they also added a muscle relaxant - tramadol at the same time. After just about a week or less I started having bad rls during the day. My doctor said that didn't make since because both drugs tramadol and cymbalta are used to treat RLS too. She actually thought I'd be able to drop the requip after the change. It did get a little better after I'd taken it for a while but sometimes I still have to take an extra requip during the day. It is a little scary when my legs jump and jerk when I'm driving.