hi april,
i take diamox & topamax together, but not all 3. i have never been on lasix. i am not confident that the 2 i am on is the wisest of decisions being made for me, but i live in a rural area with limited resources, so i feel like it is all or nothing until i can get to the specialist with the knowledge i need.
i understand your questioning, that cocktail sounds very worryisome to me. do your own research and see what you can find out. also discuss some things with your pharmacy. i alsways have mine cross reference things for interactions. the even questioned my neuro's putting me on the 2 meds together because of the alerts it brought up on their end.
i wonder if you could call the IH foundation & ask them some questions about findings they may have uncovered on the usage of these 3 drugs having been used together, if ever. just a thought.

we are our own researchers, our own advocates, our own doctors many times.

take care and let us know how things turn out.

geena

Geena, I lokked up this interactions and this is what I found.

"acetazolamide topiramate
Applies to: Diamox (acetazolamide), Topamax (topiramate)

GENERALLY AVOID: Concomitant use of topiramate or zonisamide with carbonic anhydrase inhibitors may increase the risk of kidney stone formation. Topiramate and zonisamide are themselves weak carbonic anhydrase inhibitors, and agents in this class can promote stone formation by reducing urinary citrate excretion and increasing urinary pH. Coadministration with other carbonic anhydrase inhibitors may also potentiate the risk of oligohidrosis and hyperthermia associated occasionally with the use of topiramate and zonisamide, particularly in pediatric patients. Carbonic anhydrase inhibitors can alter electrolyte and fluid balance and predispose patients to heat-related disorders, especially in hot weather. Oligohidrosis and hyperthermia are sometimes associated with serious sequelae but may be preventable by prompt recognition of symptoms and appropriate treatment.

MANAGEMENT: Use of topiramate or zonisamide with other carbonic anhydrase inhibitors should be avoided or otherwise approached with caution. Increased fluid intake is recommended to increase urinary output, which lowers the concentration of substances involved in stone formation. Patients, particularly pediatric patients, should be monitored closely for evidence of decreased sweating and increased body temperature, especially in warm or hot weather. Proper hydration before and during vigorous activities or exposure to warm temperatures is recommended. Patients (or their guardians or cavegivers) should contact their physician immediately if they develop signs or symptoms of kidney stones such as sudden back pain, abdominal pain and/or blood in the urine, of if they are not sweating as usual, with or without a fever."

WHAT THE HECK MAN!!!! WE ALREADY HAVE IIH AND NOW THEY WANNA GIVE US KIDNEY STONES TOO!!!! NOT COOL!

Topomax also can cause increased optic nerve pressure causing permanent blindness.

http://www.medications.com/topamax/browse

In my very limited reading of the different medications, I haven't seen/heard of anyone being on this combo. I've always read that if diamox doesn't work well for people, or if they have side effects, then often the next drug prescribed is lasix.

Have you ever seen a neuro-optho for this? It seems like they have more experience with IIH and aren't as "alarmist" as neuros and other MDs can be.

I am on Diamox & Lasix 20mg a day. I take the lasix for another condition. The problem that I have found with this combo is that I get dehydrated super fast & have worse headaches. A problem that being dehydrated is that it can cause kidney stones. This can happen without taking any diuretic if you become dehydrated. I have yet to find my happy medium with this combo and run from bogged down to lethargic dry.

I take lasix and diamox and klor-con which is potassium so that I don't get the cramping etc. You need to drink a lot!!!!! You will go to the bathroom a lot. That is a good thing. And the pressure will go down. I thought that the diamox also helps with seizures, I would ask a pharmacist, both at the same time???? Keep us posted. Hope you feel better.

At my last NO visit he added a low dosage Topamax and changed my Diamox to 750mg a day. he said it would help the headaches... but it sent me to the ER with excruciating stomach pain at 3 in the morning.. be careful and watch for side effects..

hey april,
yeah, i have encountered side effects in being on both diamox & topamax. since being on topamax, i no longer sweat, like ever. my neuro said I will really need to be concious of this come warmer weather and as i continue to excercise.... duh, you think!! LOL
lindamia, it stinks not having specialist readily available in the land of montana... have to travel 8 hours to get to one....soon.... very soon. then i will get my second opinion.
have you found out anything new april??

Thank you all for replying, i wont know exactly what they will do until my next appointment in two months, but in the mean time i do have to go see an opthmologist, well i was supposed to go today but had to rescedual, so unless the opthmlogist finds anything that would need to be delt with sooner i wont know for two months.