Parkinson's Disease Support Group
Parkinson's disease is a movement disorder often characterized by muscle rigidity, tremor, a slowing of physical movement, and in extreme cases, a loss of physical movement. The primary symptoms of Parkinsons are due to excessive muscle contraction, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the...
Pyridoxine (vitamin B 6) has been found to reduce the effects of levodopa when levodopa is taken by itself. This does not happen with the combination of carbidopa and levodopa. If you are taking levodopa by itself, do not take vitamin products containing vitamin B 6 during treatment, unless prescribed by your doctor.
Large amounts of pyridoxine are also contained in some foods such as bananas, egg yolks, lima beans, meats, peanuts, and whole grain cereals. Check with your doctor about how much of these foods you may have in your diet while you are taking levodopa. Also, ask your health care professional for help when selecting vitamin products. (mayo clinic)
by reducing your protein intake and thus vit b6 to improve levodopa response you also deprive the body of b-12 which you need for healthy nervous systems and to avoid dementia.
Abstract
We tested the hypothesis that mood, clinical manifestations and cognitive impairment of levodopa-treated Parkinson's disease (PD) patients are associated with vitamin B12 and folate deficiency...Levodopa-treated PD patients showed significantly lower serum levels of folate and vitamin B12 than neurological controls, while depressed patients had significantly lower serum folate levels as compared to non-depressed. Cognitively impaired PD patients exhibited significantly lower serum vitamin B12 levels as compared to cognitively non-impaired. In conclusion, lower folate levels were associated with depression, while lower vitamin B12 levels were associated with cognitive impairment. The effects of vitamin supplementation merit further attention and investigation.
PMID: 18055246 [PubMed - indexed for MEDLINE]
you can find b complex vitamins with little or no b6.
staying healthy is full time job for pwpd.........full time.
peace
Brer T
Large amounts of pyridoxine are also contained in some foods such as bananas, egg yolks, lima beans, meats, peanuts, and whole grain cereals. Check with your doctor about how much of these foods you may have in your diet while you are taking levodopa. Also, ask your health care professional for help when selecting vitamin products. (mayo clinic)
by reducing your protein intake and thus vit b6 to improve levodopa response you also deprive the body of b-12 which you need for healthy nervous systems and to avoid dementia.
Abstract
We tested the hypothesis that mood, clinical manifestations and cognitive impairment of levodopa-treated Parkinson's disease (PD) patients are associated with vitamin B12 and folate deficiency...Levodopa-treated PD patients showed significantly lower serum levels of folate and vitamin B12 than neurological controls, while depressed patients had significantly lower serum folate levels as compared to non-depressed. Cognitively impaired PD patients exhibited significantly lower serum vitamin B12 levels as compared to cognitively non-impaired. In conclusion, lower folate levels were associated with depression, while lower vitamin B12 levels were associated with cognitive impairment. The effects of vitamin supplementation merit further attention and investigation.
PMID: 18055246 [PubMed - indexed for MEDLINE]
you can find b complex vitamins with little or no b6.
staying healthy is full time job for pwpd.........full time.
peace
Brer T
Cool! you got to MTHFR.....the implication on pd is huge!
i do know about MTHFR and methylation....this is one of the reasons ive made stress the top priority in wellness as stress affects methylation of folic acid which as you likely know is the process by which folic acid is made usable for our cells. i also know that if MTHFR is mutated by oxidation/stress your body can no longer adequately break down toxins and heavy metals for removal. its quite a big deal and has some serious repercussions when MTHFR is defective. im hoping my focus on mitochondrial health and stress reduction addresses a reduction in oxidative stress on MTHFR. i hope i hope i hope.......
i ran across this when i found that MTHFR mutations could be a tag indicator or more importantly a cause of pd. fascinating stuff!!!!!!!!!! have you got to the C677T variant stuff? it looks like it role is in PD onset but how do we slow down pd post onset in regard to MTHFR aside from reducing stress and changing our diet? any ideas?
you rock! happy researching 22lynn!
knowledge is power!
peace
Brer T
peace
BT
BT