Hi Sandi, here's a pretty good website that explains much about Sinemet, and yes, my mom has been exhausted most of the time. She has always said she "feels wierd"..good luck

I hate it when I do that, in such a hurry! Here's the website I meant to add..

www.rxlist.com/cgi/generic/sinemet_ad.htm

When i first started Sinamet, i expected an instant result. i wanted to feel normal, all it did for me for a while was to make me feel sort of distant, and like i was not concentrating, and it wasnt working.

I was told to take it with food, but now i take it on an emmpy stomach, i feel good, and it helps greatly, this took about 3 months to feel that way

take one half tab of sinemet cr makes me feel tired weak out there cannot tolerate it at all without taking on full stomach so so tired oh take the med three times a day along with one azilect take care

Sandi,
I have been taking Sinemet just shy of two years. Fatigue and being tired had slowly become a part of my life prior to taking Sinemet and has increased with time. I know many PD drugs can cause those affects, especially the agonists. I personally believe that it is a combination of both the PD and the meds we take for our PD, especially for those who have had PD for a while, even if they have only recently been diagnosed. Additionally, many people PD do not sleep well throughout the night, so that could also contribute to issues during the day. So, I just do what I can when I am at my best and sleep when my body tells me to, regardless if it night or day.
Good luck to you.
Nicole