Pancreatitis Support Group
Chronic pancreatitis can present as episodes of acute inflammation in a previously injured pancreas, or as chronic damage with persistent pain or malabsorption. Patients with chronic pancreatitis can present with persistent abdominal pain or steatorrhea, as well as severe nausea. Some patients with chronic pancreatitis often look very sick, while others don't appear to be...
I just read an article on Valium/Diazapam study and pancreatitis. It was on induced pancreatitis in rats and the results were...to paraphrase...
That the Valium, given to some of the rats before they induced the pancreatitis, on examination afterwards had less inflammation and cell damage in the pancrease than those without. They figured out that it worked directly ( within the circulation at the cell site level) rather than remotely in the central nervous system suppression of endocrine function (NOT enzyme production suppression). More that the Valium bathed the area with something that inhibited the cytokines ( inflammatory chain of response) which would aide healing and decrease scarring in the recovery. more research was needed of course to identify the exact mechanisms of the drug effect.
So....
Has anyone out there been on Valium when you happened to have an attack?
Has anyone thought that Valium ( maybe taken for a different reason) may have also had the added benefit in helping your pancreatitis/SOD/ CP?
Thanks for your assistance.
Wishing you wellness
Lynette
That the Valium, given to some of the rats before they induced the pancreatitis, on examination afterwards had less inflammation and cell damage in the pancrease than those without. They figured out that it worked directly ( within the circulation at the cell site level) rather than remotely in the central nervous system suppression of endocrine function (NOT enzyme production suppression). More that the Valium bathed the area with something that inhibited the cytokines ( inflammatory chain of response) which would aide healing and decrease scarring in the recovery. more research was needed of course to identify the exact mechanisms of the drug effect.
So....
Has anyone out there been on Valium when you happened to have an attack?
Has anyone thought that Valium ( maybe taken for a different reason) may have also had the added benefit in helping your pancreatitis/SOD/ CP?
Thanks for your assistance.
Wishing you wellness
Lynette
It's been a long time since you posted your query. I must tell you that perhaps the Valium hypothesis is correct. I have suffered 20 episodes of AP over the last 18 years, developed an intra-ductal cyst, and been diagnosed CP. Being an occasional user of Valium, I discovered that my last crisis was absolutely resolved after taking 5mg of diazepam. I did not even go to the hospital, as the episode finished three hours later. After that, I take one 2,5 mg pill on a daily basis and it has been almost three years without visiting the emergency room. Only a few times, when I felt the prodrome of an attack I took 5 mg, and repeat it the next day twice. I also use an intestinal motility helper (Cidine; Cinitaprida 1 mg) for a couple of days. The crisis has never appeared ever since. I contacted the authors of the study, informing them that my experience could be a confirmation of their hypothesis in humans, but never receive an answer. Hope it helps.