Remember, the side effects of Mestinon are the symptoms of the disease. My doctor didn't want me to take more than 60 mg 5 times a day. I know there are more on here that take more, with the approval of their doctor.

I sometimes can feel a difference with 15 mg of mestinon. I break the pills in half and then half again. When I was adjusting up or down, I would go by 30 mg increase or decrease, then by 15mg until I felt improvement. We should never "play with our medicines" unless our doctor is ok with it. Sometimes, too, I would adjust my doses closer together in the morning and farther in the afternoon. Never more than 4 -5 hours apart. I could not tolerate timespan -which should not be cut in half, by the way. It's time release and you could get too much in your system. Confirmed by my doc and pharmacist.

For a long time I only took 30 mg. Now, I don't take any, because my muscle weakness isn't my main symptom, fatigue is. Each of us are different, and I have several other autoimmune diseases and other illnesses to deal with.

I hope you find a dose that's right for you.

Barbel

It's good that you are pursuing treatment. I think progression is faster if MG is untreated.

Hi Barbel, thanks for your prompt feedback. Feeling like none of this weirdness was happening prior to mestinon other than the dreaded worsening of current symptoms after starting prednisone. I'm scared of it now frankly. I took the overnight and a regular 60 this morning. It's about time for next dose or either 120 or 60 but I'm playing by ear. I am very sleepy and think that is playing a huge role in my eyelid droop as when i rest my eyes it opens up a lil more. Although the time changed I'm still up at the same time.

So since not forcibly closed like yesterday and less mestinon this morning, I'm hoping that means the prednisone is kicking in although still not at optimal dose of 60.

Sounds simple enuf but what do I mean the SEs of mestinon are the symptoms of the disease? Do you mean they mirror the same symptoms or like prednisone your current symptoms worsen?

You mention having several other AIs Boy do I know about comprbidity!! Makes me feel so sad. BUT I was blessed to literally beat MS with diet and naltrexone. I have to know I can get beyond this too with Gods Help!

Thank you so much again for your feedback!

SE of mestinon for me was increased muscle weakness. There were a couple of times that I was taking too much mestinon and I thought that MG was getting worse, but instead it was more controlled and I actually needed less mestinon. It takes a while to figure out what dose you need, but I am confident that you will figure it out.

Thanks again. Thus far today no more mestinon. Do t feel like I'm any worse without it. Rather when I can rest my eyes the lid is more responsive. I'm thinking mestinon (if you're lucky enuf for it to work for you) can mask if the prednisone is starting to take effect.

Is the consensus as prednisone is working less mestinon is needed? Thoughts on why it would like a charm first 3 doses and then nothing?

As the disease gets under control, less mestinon is needed. I'm very sensitive to it.

Makes sense thanks. Good way to guage improvement. Thoughts on why it worked for 3 doses then not? Only diff was that Friday's dose worked great, was emotionally stressful day. Early Saturday didn't take until was sure eyesymptoms retuned. They returned indeed and harder and mestinon minimal help since. Perhaps the added stress pushed me further away from progress- forcing me to higher dosages. Now wondering if I took another 60mg would it help again. Is there an ebb and flow to it?