From what I have seen on here, it works better for some, worse for others, but definitely something to try... I use it at bedtime to make sure i have a happy wake up. Without it, i am pretty bad in the morning from nothing in my system. During the day however, it was much less effective than the normal mestonin that i take every 4 hours or so. Best of luck in trying something new.. ya never know what the right combination will be for you....

Hi: I've had good luck with the timespan. I just have to take it with a meal, or get stomach cramps. For me, the regular tablets gave me a roller coaster ride, where the timespan is pretty smooth. I take one with breakfast, and one with dinner. Best of luck.

Hi Carly! Ask your Neuro or PCP - about a Rx of Reglan.
To help - with the Gastroparesis. I started a dose of 5mg daily, several months ago (1/2 of a 10mg pill). It is making a difference, a significant improvement. - Ross
(I could probably take the full 10mg, with no problem. But the 5mg dose is working fine - so good enough.)

Timespan releases irregularly. I use to take it at night, and that was ok. Now I don't need it at night. I now take 30 MG Mestinon every 1-2 hours during the day. It works better when there is a constant stream in your system. Wishing you the best with your new Rx!

I use it at night and it's been amazing--I finally breathe all night long! I had some significant stomach issues with it at first, but I seem to have adjusted.

I take Timespan at night. I tried taking it through the day but found it too inconsistent and caused a little anxiety, something my first neuro stated was a side effect for some.

FWIW

I was on Timespan BID with all kinds of side effects, literally reluctant to leave the house for fear of an embarrassing event.

My new specialist - he's 80+, been doing MG for 50 years, bless him - has reduced me to 60mg TID with Prednisone and Imuran, and has restored the quality of my life.

Admittedly, I have a mild case: Double vision, minor difficulty swallowing.

Well, I've only had two doses of TSpan. The one I took at night went over just fine. The one I took for the day made me feel unwell. (and not just gut issues)

Then, I had to restart some Diamox for my IIH and that has made me feel even worse.

I am in bed resting, resting. I told my neuro that the Diamox made my mg feel worse and he said to just do low dose. That doesn't seem to matter.

Sigh

Many people only use the time span at night so they wake up without being behind on doseage. Maybe it would work better for you to try it that way.

I am able to use it BID and use the shorter acting on top of it but I seem to have fewer of the GI symptoms so far.

My neuro told me it releases somewhat unevenly but it good at night and if used in the day the 60 mg short acting or splitting it to 30mg can be added. I find I have to fine tune mine a lot depending on other meds and activity.

Sounds like Ross had some ideas on the Reglan for GI symptoms.
Hope you find the combination that works for you soon....Marie