Try this, before you go take a couple of tylenol (or something) then later that day a couple more,, see how that does for you. If you are still having the pains let your doc know.

The fatigue, for sure! It is getting less and I miss it...I liked sleeping afterwards. Like you said headaches at one of the most common side affects, handled by tylenol or something like that.

Here is a post from gasgurl she had digestive issues. She takes something to coat her stomach before the infusion & she asked tjhem to slow the infusion down and she said it helped.

My infusion nurse says she has one person who gets hives and she has slowed the infusion down a lot for that person and it helps her. It's more that 2 hours but Ui forget how much my Ty nurse said she slowed it down for that person.

I'm lucky, I don't get side affects but it sounds miserable for the people who get them! The fatigue lessened for me when I mad sure I was fluidized before the infusion, drinking a little extra the night before and morning of.....but I tend to not drink a lot because of incontince issues.

http://www.dailystrength.org/groups/tysabri-users/discussions/messages/8463488

It seemed like 'about' after the 6th infusion things stabilized and find out the benefit of Ty for the person, perhaps it just takes that long to find out what works for them. Being fluidized was important for me.

I've been on Tysabri for two years now. I did get headaches-sometimes really bad and I'd fall asleep for the infusion and a while after. It gradually stopped and I looked foward to the infusions. It really helped alot. I'm seeking info now as I'm experiencing what I believe is a flare up. But that's just me, I've been under a lot ofd stress lately. Good luck with the infusions! :)