I found this: "The FDA lists no interactions between Tecfidera and alcohol. However, its best to take some time before drinking alcohol. First, understand the effects the medication might have on you. If youve recently begun taking Tecfidera, abstain from alcohol for a week to 10 days. This allows your body enough time to acclimate to the drug. In that window of time, you should get a sense of how your body responds to it.

Even if your doctor clears you to drink alcohol while taking Tecfidera, do so in moderation. Excessive alcohol consumption can negatively affect your physical health. This can cause setbacks and may lead to worsening MS symptoms."

Here is the source: http://www.healthline.com/health/multiple-sclerosis/tecfidera-alcohol#HowItWorks2

I haven't asked about alcohol and Tecfidera per se' but have been told that my glass of wine should be alright with Rebif before. Since I paid attention to Daniel Amen, MD though, I'm thinking twice about the wine. He makes some great points. He has done tens of thousands of brain scans so I feel confident that there is plenty of merit to his findings. https://www.youtube.com/watch?v=esPRsT-lmw8

my neuro told me that having MS means one drink (alcohol) is equal to three.

Guess that makes me a cheap drunk.

They should have a toll free number to call to ask. Call the Tecfidera line. But I would try with moderation, maybe start with one drink only and see what the effect is.

Careful with alcohol and any medication. It doesn't mix with provigil I understand. I don't drink at all. I do smoke occasionally but in small controlled instances and no driving is involved or when I have to do much walking. I worry about balance problems.