My neuro wants to me to start on a new drug. No interferons for me- already tried them, and Copaxone. He suggested either Tysabri or Gilenya. I'm leaning toward Tysabri as it has been around longer. The PML is not a nice side dish, but its been almost 19 yrs and I have not gone progressive yet and the Dr is concerned that it might be just around the corner so efficacy is a major selling point. I am still very functional and daily life is not impacted much by my symptoms. But I am also young- 32- and I'd like to stay functional and active with my four young kids as long as possible. I guess I'm concerned about the length of time being on Tysabri and it feels like I'm pulling out the big guns early in the game. I'd like to hear anyone's advice/stories on deciding and starting on Tysabri and how it has helped you.
Or I may choose secret option #3 and get pregnant. The first four went well.

Thanks to anyone who wants to share/weigh in on this.