Seeing that you have been tested for everything else physically and neurological and blood work has been done and all came back negative i would say yes. I would say its a good thing lession arent found yet that mean your body is in fact attacking itself but not leaving scar tissue. Hugs!

Couple of questions:

I assume they tested you and you were negative for Lyme's Disease, Lupus (ANA test), ALS (Lou Gehrig's disease) and B12 deficiency, etc?

If you absorb B12 they the test will show B12 level is fine...which IF you can metabolize it into Methyl-B12. IF you can not then while the B12 test comes back fine you would be deficient in methyl B12 thus your myelin does not have what it needs to renew itself and will give you "MS like symptoms"

Did they give you METHYL- B12 sub-lingual tablets for a few months to see if it reduces symptoms? I ask because some people can absorb B12 but have issues activate it (reshape or metabolizing it) so you can use it. They can not test for methyl-B12 but they can either give you cheap methyl-B12 for 3-6 months to see if it helps or they can test your genetics (MTHFR test ).

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The other things I would look into are getting an immune test ie
1.) MRT test from LEAP
http://nowleap.com/the-patented-mediator-release-test-mrt/
It tests over 150 foods and chemicals to find out if these foods increase LGs, PGs (steroids block these chemicals and their inflammatory response). It also tests to find if these foods increase cytokines ie IL-7 that increase T-cells which all can contribute toward symptoms. Then you reduce or eliminate foods that cause your INDIVIDUAL immune response problems that might be contributing toward your disease symptoms.

2.) GI testing from Genova Diagnostics ie URL below is also another good idea because 70-80% of the mature immune system is found in the gut. If the gut is not working correctly it can affect your immune system (ie inflammation and T-cells)
https://www.gdx.net/product/gi-effects-comprehensive-stool-test

Wish you the best of luck working with your doctor to help your health,
EP

Were you diagnosed by an MS neurologist? I myself have PPMS, and it is harder to diagnose (as there are no sudden episodes).
My MRI was different tan yours, but I was older tan you when the scans were done. It is better if they are detecting it earlier on. As far as symptoms, they seem to be in line (I also suffer from fatigue, spasticity, urinary retension. . .)

my neuro thinks I have micro lesions which are not showing up on the MRI and like you said my symptoms are in line but I am much younger than most diagnosed with this type so scans may not show larger lesions in my spine yet. Ive been sent to uf hospital for a second look and they re ran everything. Evokes emg lp Lyme b12 and other rare genetic disorders and only thing that keeps coming back is the lp with OCBands and WBC And proteins. Have not tried methyl b12 that's not a bad idea if my liver doesn't metabolize b12 but they didn't think that was it cause they tested me and put me on b12 and tested me again and my body adjusted to it so irk. They did an immune panel also. Ive had 30+ vials of blood taken within a few days several times so many panels done its hard to keep track.

Meg for ana and als also

*neg

B12 and Methyl B12 are both water soluble (pee them out if you have too much ) but they are not the same thing. B12 is like absorbing an UN-cut (unshaped) house key into your body. Methyl-B12 is like absorbing a already shaped house that once absorbed can work even if your body has issue shaping (metabolizing/activating by shaping) this vitamin. I really do not know why docs don't just give you methyl B12 to see if it helps.

I only think a small sliver of MS population has this as an issue..but take a look into this as it is a CHEAP water soluble nutrient (you pee out if you have too much).

The tests you had are to determine WHAT you have. They will help give you a proper diagnosis. These tests,more than likely, did NOT include the 2 tests I mentioned above. These tests go toward finding contributing causes of what is increasing inflammation and T-cell activation in your body. It is not root cause but what is contributing to your symptoms.

Good luck to you,
EP

PS my husband has had RRMS for over 11 years (dx around age 30). I have done a TON of research on this and once we eliminated problem foods, added supplements (fish oil, VITAMIN D3, CoEnzyme Q10, GOOD multivitamin with lots of B vitamins, etc) his relapses went from every 3.5 months to 4.5 years and now it has been over 5 years since last relapse. Doctors can not believe how good he is doing. He is NOT cured but we have slowed the beast.

I just looked at the sites and i know o havent done stool sample. Ill ask about the gi and the mrt next visit i have at the university. If i understand correctly these will give some understanding as to why my symptoms are there and how my ms works?

EPagain. Thanks for all the information and linms im his wife so we appreciate all the info we can get.

*links

I think that usually PPMS is normally detected in older people is that, as it doesn't include the telltale optic neuritis or similar it takes longer to detect. The fact that I had so many 'black holes' (lesions) indicates it had been working at me for awhile, it was just asymptomatic for a good while (I was dxed at 38). I personally have a clear brain stem & spine.

The 2 tests I mention go toward finding contributing causes of what is increasing inflammation and T-cell activation in your body. It is not root cause but what is contributing to your symptoms.

So part of MS is where specific T-cells are doing damage to myelin. One of these tests looks at what foods /chemicals (150+) and finds out which ones are increasing Cytokines->IL-7 which trigger..T-cells. If you have an autoimmune disease you really want to avoid increasing T-cells which are a part of your immune system.

On the topic of immune system, 70-80% of the mature immune system is found in the GI. If you have bad bacteria, fungi, parasites etc in your gut this can increase inflammation (part of immune system) and other parts of the immune process. The second test looks at what you can do to improve gut health and therefore proper immune function (ie decreasing inflammation ,etc).

In addition to methyl B vitamins I would encourage you to speak to a nutritionist or doctor about also looking into vitamin D3 and trying to get your levels up to between 70-90. Research shows that those with higher levels of D3 have less disease activity.
Vitamin D3 info and research link http://www.dailystrength.org/groups/loved-ones-who-support-someone-with-ms/discussions/messages/14690178

You need fish oil, olive oil, nuts (aka fat) to absorb fat soluble Vitamin D3, plus K2 to properly deal with the increased absorption of calcium (D3 tells gut to absorb calcium).

Also know that if you are highly stressed and or have high inflammation in the body (ie GI inflammation) then your body makes natural steroid called Cortisol. D3 is turned into a seco-steroid. What is my point in telling you this?? Cortisol and D3 compete for cell receptors telling the cells to function. If you have tons of extra cortisol (due to chronic inflam or stress) then D3 will not work correctly.

Best wishes to you,
EP

Thank you. I have been dealing with all this for at least 2 years that i know of when i injured my lumbar and slowed down and never picked back up. Still have a lot to figure out. I do know that the sun fatigues me badly even just a little bit always has because im irish lol but much worse now. I dont have a d deficiency actually quite good even though my diet isnt that great. My gool is to find what to eat that gives me more umph and reduce muscle rigidity and my fatigue. Thanks for the tips and i will bring them up on my follow up! Anne ppms usually stays in the spine for the majority at least at first your right.

I have Dx of PPMS after similar/extensive testing pattern. While the FDA makes it's determination on ocrelizumab Roche lab); my MS Neurologist has suggested pharmaceutical grade Biotin (B7, Vitamin H) 100 mg 3x per day. Small studies in France showed promising results for PPMS and SPMS.
http://www.ncbi.nlm.nih.gov/pubmed/26327679
Wishing you the best

Yeah my neuro told me about ocrelizumab looks like it got fda approval for rrms and ppms earlier this month. He said should be out in 6 months then i start that. Does the b7 h work?