Guess we should all consider tricyclic antidepressants since they restore norepinephrine (same) but the SSRI and SNRI's do not! So, they make you fat but at least maybe MS symptoms won't be as harsh or maybe gone? Got this from Stu today as well. So maybe there is something to this.

Thank you for sharing this information.

Best wishes to you,
EP

very interesting, thanks for posting :-)

I hope they keep investigating this. I would be happy to gain a little weight, maybe I wouldn't be so cold all the time.

It is very interesting that to treat deficiency of noradrenaline, they give people a hypertension drug , I think levarternol. It made me think of this study

http://med.stanford.edu/ism/2009/august/lisinopril.html

where MS patients were treated with lisinopril- another hypertension drug.
I don't need blood pressure medication, or antidepressnats. But hopefully they can find another way to facilitate noradremaline production, or figure out what is inhibiting it in MS patients.

Given the effects the drugs have on the blood and veins, also makes me wonder more about CCSVI and how it might fit in.

Reply#5

I completely agree. I don't think CCSVI is the cure. However I think if we can find out WHY some with MS have issues with their veins and certain deficiencies. We will get MUCH closer to root cause and therefore much closer to better treatment protocols.

Again thanks for this post Brianap ( :
EP

Thank you brianap for the informative links! It's interesting you bring up being cold all the time. That's what I was like a few weeks ago - I felt ice cold from the inside out, my temp ran around 97.4, and my hands and feet were like icicles. These articles definitely give food for thought about the relation of circulation to some people's symptoms.

Yes, thanks for the links. I noticed that on the second link that in "Related News", it said "Study yields GOLD MINE of potential drug targets for treating multiple sclerosis" and had a link to another article about this same doctor (Lawrence Steinman) who was working on the drug lisinopril.

Interesting, they are all looking for "treatments", and they are consider us "gold mines". I want the cause and the cure, thank you very much, d*** it doctors.

I am wondering why the blood pressure meds aren't working already on the those who happen to have high blood pressure. Anyone out there on high blood pressure medicine? And does it affect your MS? Just wondering.

Thanks again for the articles, brianap.

I too take lisinopril too and haven't noticed any change in my MS.

I'm on a beta blocker and i just notice less headaches,less muscle tension and less anxiety.

POSSIBLE link!

Interesting info. my friend...

But EVERYTHING is still a POSSIBLE LINK until seriously proven otherwise, not just a possible link, but the actual cause. It is good to have many theories & do allot of research though, until we find one day the REAL culprit of this disease & one day we will, bumping into many theories along the way trying to figure it all out. It's part of the whole process. :-)

My Neuro. says...he's kind of like a detective in many ways because MS is so varied. Makes allot of sense & it's awesome he is willing & cares enough to do the leg work to figure out my health puzzle...heack, the health puzzle in general that is MS & Neurological diseases to begin with. :-)

Take care,
Stay sane!