Has anyone experienced joint problems with MS? I went through a bout about 3 months ago of EXCRUCIATING shoulder pain, but it only came on at night. I went to the ortho doc and had x-rays, and there was no evidence of a rotator cuff injury or impingement. The pain eventually subsided, and now it only comes around about every 2 weeks or so. When it does come, the only thing that will relieve it is a heating pad and heavy doses of painkillers, lol. Any ideas?