To my best knowledge Prednisone will + affect areas of inflammation. However, it will not "cure" anything, and it is not for long term use. I was taking this due to a back injury (also taken it for allergic reaction to spider bite). I am not sure if it had any affect on my HS because I still have outbreaks. So since HS involves lots of inflammation, it makes since it would help the inflamed areas where HS has attacked us. Once you stop taking it, it is doubtful you would continue to have the affects of the med. as the primary problem hasn't resolved (HS) on it's on or via other treatment. Please let us know how this works out long term, and I am so happy that you have some relief of your HS.

Your right HSGirl I am only taking the steroids for a short time so it probably won;t do anything long term, unfortunately. I don't like the way the prednisone makes me feel anyway. I think I would just assume have the outbreak.

I strained my back and was prescribed Prednisone. Man it cleared me up quick. My dermatologist wont give it to me ...UGHHH

Hi Everybody,
This skin disorder sucks! However, I have a found a way to clear breakouts quickly!
I don't know about prednisone, but I can tell you what I do.... It takes some effort, but it works!
As soon as you feel an out break coming. Drink a tablespoon of turmeric powder and almond milk 1 to 2 times per day and cut down on sugar and caffeine. You can also drink 2 cups of turmeric tea mixed with sour sop tea per day. Any vegetable market or health food store will carry both teas.
In addition, make a paste of 1 tsp of turmeric powder, 2 drops of 100% tea tree oil, 1 tsp of sea salt and 2 tsp of almond milk. Apply to the area (using a gauze to cover because turmeric can stain) and leave it on for about 20min 2 times per day. DO NOT LEAVE IT ON LONGER THAN 20 MINS at a time to avoid irritating your skin. The bump will shrink in 24 hours.
In between the paste treatments, apply 2 pumps of antibiotic hand soap and 1 drop of 100% tea tree oil on the area. Leave on for 10min and wash off. I do this in the morning and at night BEFORE showering. This will cut the pain.
Also, buy some Epson salt and take a bath for about 30 mins (try to softly rub the area to get the blood flowing while soaking, even if it's soar!!) two to three times a week. You can take Ibuprofen for pain.
I promise it will either open or dissipate.
If it does open, help it drain and then apply triple antibiotic ointment and pure aloe vera. Cover during day but let it breath as much as possible. Just like acne. This will keep it from spreading and help it heal quickly.
FYI
Make your own sea water from the supermarket sea salt mixed in water, it makes an excellent soak! Either soak a cloth in a warm mix of it or just pour over the area, dry and go to bed. It will clear an outbreak up in a week!!!! True story, I went away and got in the ocean every day, it cleared up in three days!!
I know it's a lot but it's better than taking antibiotics every month or worse:-(
Good Luck!