Well this one defiantly needs bumping. I dont have the answer but Im sure some of us here do.Hope you ghave a great day my friend. :-)

I did the GS-5885/7977 12-week trial with Riba. I had bad sides from the Riba, but worked most days. I drove with no problem, kept my housework up most days, and walked the dog on occasion. Others here have said they had either mild sides or no sides at all. Have you found a trial?

I have contacted Gilead about a trial they posted to be open but have not heard back. Talked with the nurse from the hep clinic and she said that I would be able to take a non-evasive treatment in November. Not sure if I trust what she said since they have screwed up a few times with paperwork and my appointment dates in the past. Like catmagic said to me...hope.

Thanks SandyDo. I wondered about the sides since I know I have to work during the fall. I am employed by a school system so it would be perfect to take the tx during summer break.

I am currently on all oral Riba, Fladapavir and an investigative drug - BI Phase III trial - .

Riba side effects I experienced:
- VERY sun sensitive! Like OUCH!
- some MILD nausea
- pretty severe insomnia, but I was prescribed sleeping meds
- I developed anmeia and shortness of breath on 1000 mg/day Riba. They reduced it to 600 and I felt better almost immediately. They will soon bump me back up to 800 mg/day
- some moodiness, some headaches and some anxiety, but I think all related to the insomnia

IF I was working i would have been able to (of course deopending on how physical your work is - and also how stressful)!

I can tel you that I went to my aerobic exercise class until the anemia (I was apprently on placebo the first 8 weeks, and had all above reactions after that when i obviously was actually ON RIBA!).

But once the dose was reduced i was able to exercise again. Unpleasant but definately tolerable is how I would define it overall.

NOW....old school thinking was to *not* redeuce dose if side effects are bad. There was fear it would interfere with the results, but it's been poroven untrue. However, it WILL depend on the doc conducting the study... how po-to-date they are with that. If the anemia is SEVERE - HGB below 8 - on my study, the pharm co INSISTS you lower the dose. My doc lowered me when my HGB was 9.2 and will raise it back up when it gets to 11.

Good luck. My study has an 85%+ success rate!

I also had anemia...in the 800s at times. They also reduced my dosage from 1000 to 600 and although it helped, the anemia didn't get much better. It stayed in the 8s and 9s the full 12 weeks.

Just FYI to all - the Gilead ION 3 trials (the 8 to 12 week one) are full - 600 people nationwide - and so are the 12 to 24 week ones. I'm speaking of the trials with Sofosbuvir/Ledipasvir with or w/out Riba. This info. came to me from a person at Gilead this morning via e/mail.

Damn, right?

I was told from the nurse practitioner that my doc is not treating anyone with a triple treatment and will be waiting for the new, less evasive drugs to give to their patients. I asked when that would be and the response was "I do not know but hopefully by the end of this year".