That is so strange how each geno is prevalent in certain countries. Wonder what the connection is?

I thought I saw someone post on here that they had 2 different genos.

Interesting. I ask myself idly whether 2 types in one host will evolve into another type, and if 2 types need 2 separate treatments? Can you even do that?

How the Heck did I get .3a ???
I lived in the UK I got it there .....
NEVER been to Australia ...lolol

Oh and 3a is the oldest genotype .
I read a historical book that reckons it was around BCE. ???

Please name the source of this data, and if possible a link to this data.

Hank,

I've seen this cited from several sources.

Go here: http://www.hepcprimer.com/tests/geno-exp.html

At the bottom it states: nfo taken from Genotypes and Genetic Variation of Hepatitis C Virus by G. Maerterns & L. Stuyver, reviewed by Dr Greg Dore of the National Centre in HIV Epidemiology & Clinical Research. From The Hep C Review; Ed 23, December 1998; Paul Harvey

Think about this for a bit. We have over 10 genotypes and subtypes developing at the same time in different areas.

How was it spread from generation to generation? One can envision blood being shared in battle - two people get stabbed with the same sword. But then one of the infected would have to repeat it with the next generation.

And that exact same pattern would have have to repeated itself for all of the various subtypes.

It doesn't make sense to me. But over and over we are told it's not sexually transmitted. Ok, so please explain to me a model for how we developed the various genotypes.

Havehope, you could be right, it makes sense to me.

Very interesting. Thanks for sharing

Hi Oso de Panda con sangre Cubano!

Yes, I have seen it in other sources also. The reason why I asked was because since Texan62 is relatively new here, yet as equally important as the rest of us are. I just wanted to suggest that those of us who have been in here for quite some time as well as newbies would like to have any relevant technical information regarding the topics to be referenced or cited. So that they could add the complete reference in their own archives of data and weblinks. As you know this is a common practice in this forum.

On another note, it's good to see you staying around and still SVR!
The blanket assumption that HCV is not at all transmitted nor has it ever been transmitted via sex to me has also been questionable. Especially because of some studies do show that the virus can indeed be spread thru sex. Even though the numbers are so very rare and low in the interpretation of the data based on percentages shown in these studies.

Btw, as this reply is being written, I currently don't have the referenced study to cite for this available to include in this post. But I will follow up with posting the links to the referenced data just as soon as I find it within my archives which may take a day or two because of the size of my library. So please bear with me and please remind me if I forget to follow up because I can easily become distracted with something else and get lost in doing other stuff that isn't even on the proverbial radar or *sonar of my mind. So please remind me if I forget.

* I keep hearing other folks whom I haven't communicated with for such a long time requesting information in my mind sometimes.

Dios te Bendigas Compay!

Good points HH.

To me, the very fact that there are different genotypes is a convincing argument that the virus has the ability to adapt and change over time when confined to a specific geographical area. And the fact that a high percentage of those infected have a spontaneous cure seems to indicate that many have a natural ability to fight the virus. http://www.ncbi.nlm.nih.gov/pubmed/12851873

So, one then begins to wonder how the virus will react to the present cures? Will it continue to adapt itself, and develop into a new, drug resistant subtype? If so, how will we humans react to the new subtype, will we develop an ability to fight it as well?

Inquiring minds want to know.

Bob
El Oso Curioso

The young tend to overcome the virus, leaving only the antibodies as evidence.

Initial testing is almost always for the presence of antibodies only.
(Definitive RnA testing is moot w/out antibodies). Cost determines this.

My own 14 yr old son killed this virus on his own at some point in his youth. He has never missed school due to illness and we do not know how or when he was exposed.

My wife of 16 years is and remains negative, as does my 12 yr old son.

I "had" hep C and cirrhosis before I ever met my wife.

I do my own homework, and rarely feel the need to cite zip.
This is my way of encouraging others to do their own research.

I wrote this because there are obvious mysteries yet to be solved as Mr Oso has pointed out.

Also, I have no concept or grasp of the statistical breakdown between the "exposed and cleared" and those who have active RnA. This is a reporting problem in my mind....

Once you test "positive" you become the reported statistic...
regardless of whether you are "infectious" or not.

"But what doe's it all mean Basil?"

Basil says: "The more you think you know - the less you really do. (;>)

Sign me up...I agree Hank!

I've already forgotten most things twice.

This is so my hard drive has enough room to relearn basic items like
how long it takes to cook grits or nuke frozen mcmuffins.

I'm just not a lactulose kinda guy, if ya know what I mean.

thank you for the info. I have wanted to learn more about genotypes. I am super curious as to treatment options, success and/or failure , depending on genotype of person.

I had a friend with genotype 1 b, I think. she was a U.S. native but as a nurse , said she contracted it from a needle stick at work.