Hepatitis C Support Group

Hepatitis C is a blood-borne viral disease which can cause liver inflammation, fibrosis, cirrhosis and liver cancer. The hepatitis C virus (HCV) is spread by blood-to-blood contact with an infected person's blood. Many people with HCV infection have no symptoms and are unaware of the need to seek treatment. Hepatitis C infects an estimated 150-200 million people worldwide.

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Gilead ION-1 Update March 26, 2013

ImKramer
ImKramer
Gilead Announces Update on Phase 3 Study of Oral Fixed-Dose Combination of Sofosbuvir and Ledipasvir for Genotype 1 Hepatitis C Patients
http://www.gilead.com/pr_1800517
deleted_user
deleted_user
from the article:
"... ION-2 is evaluating sofosbuvir/ledipasvir with RBV for 12 weeks, and with and without RBV for 24 weeks, among 400 treatment-experienced genotype 1 HCV patients..."

Does that mean that the 12 week without riba has been extended to 24 weeks or am I missing something?
ImKramer
ImKramer
ION-2 is based on the results of ION-1 and takes it to the next level -
treatment experienced not naive, so the mix is a little more aggressive.
I don't see a 12 week no Riba arm like in ION-1 Only arm with no Riba is 24 weeks of sofosbuvir/ledipasvir.
Are we on the same page?
I have more and more cognitive challenges these days.
deleted_user
deleted_user
honestly, I'm pretty fucked up now and shouldn't attempt to be posting anything coherent. But I was certain there was an arm on this trial without riba for 12 weeks and I thought there was chatter about possibly extending it to 24 weeks. I now see after reading your link and googling that I invented that. I was so sure it existed and was so surprised that it did only in my head. Maybe tomorrow I'll realize that this was just a lapse and not total ignorance...better stop this post. sorry.
ImKramer
ImKramer
No problem Kat. I post these after a quick read and often glean more later.
ION-2 is the next phase for the "hard to treat" population. Hey I might get a call; wouldn't that be cool?? (not holding breath though).