hum

Yeah hum indeed

Perhaps TX with other drugs will confer a better outcome than SOC.

I was told by The Liver Centre that if one gets rid of the virus (cirrhotics) before liver failure then transplant can be avoided.

bummer

Yikes!

,,it's just a study. I hesitate to share shitty news. I wish I hadn't just knowing how we tend to worry.

Good to know, glad you posted.
It re enforces the need for vigilance even with svr sustained. Wise ones will not return to alcohol.

Shadow, Alan sums it up pretty well in his comments.

COMMENTS BY ALAN FRANCISCUS, EDITOR-IN-CHIEF, HCV ADVOCATE:

This is an important study for testing the durability of an SVR or viral cure and continued disease progression in those with cirrhosis. The results and conclusions of the study include:

There were no cases of relapse once an SVR was achieved.

Improvements in APRI (non-invasive method to gauge disease progression), and biochemical functions in all of the study participants (except 5 patients who had newly acquired hepatitis) occurred in those who were treated.

Importantly, 22.2% of those who had pre-treatment cirrhosis developed liver cancer and 11.1% died of liver related deaths.

The study confirmed two important issuesthe durability of an SVR was maintained in all patients and those patients with pre-treatment cirrhosis can continue to progress on to serious disease which means that people with cirrhosis who achieve an SVR or viral cure must be carefully monitored since the rate of severe disease progression is relatively high.

So does that mean

> those patients with pre-treatment cirrhosis can continue to progress on to serious disease which means that people with cirrhosis who achieve an SVR or viral cure must be carefully monitored since the rate of severe disease progression is relatively high

Yes that is what I get from this study report
"patients with pre-treatment cirrhosis can continue to progress on to serious disease which means that people with cirrhosis who achieve an SVR or viral cure must be carefully monitored since the rate of severe disease progression is relatively high. "

But the fact that cirrhosis can lead to liver CA is nothing new,even outside of Hepatitis C.
The good news here I suppose is that SVR is maintained.

It was part of the study and with only 145 participants in that study as opposed to the one I posted yesterday with over 996 patients, makes it rather small...

Here's another article:

hepatitiscresearchandnewsupdates.blogspot.com/2011/01/impact-of-sustained-virological.html#.USVe4vL

And another one:

http://hepatitiscresearchandnewsupdates.blogspot.com/2010/11/aasld-long-term-outcomes-better-with.html#.USVhYvLgeSo

Nonetheless, relapse does happen to patients with long term SVR no matter how small the percentage because it does happen as rarely as it is.

Respectfully,
Henry