Second medications was sofosbuvir. Sorry about it not coming out on initial comment.

Daclatasvir is not even approved in canada yet so I havent seen much about it
..I have 3a and am currently at almost 18 weeks into 24 with Sov/Riba
I am undie so far but It will be 3-6 months after the end of tx before I know whether I will relapse ..
I previously tried inf/Riba the Peg/riba but neither even got rid of the virus ..
Best of luck with Daclatasvir ..I hear it is great for the geno 3's

Do I understand correctly:
Your 1st tx was interf & riba. 2nd tx was ssofus & riba? For how long?
They are suggesting tx 3 be riba & declared for 24 weeks?

I assume yes you would need a 24 we tx but I can't reply to decla I don't know enough about it.
With your combo of health issues, your team can best advise you.

I did interf & riba. Then sofus & riba. Waiting for a 3rd tx, perhaps harvoni 24 weeks.
Android would 't obey my spelling!

You know riba causes anemia, it will also play with bi polar. I could not complete my 2 previous tx because of sides with riba. I will not take riba ever ever again. I will live with hcv if can't treat successfully without riba.

I did 24 weeks of Sovaldi (which is sofosbuvir, I believe) and ribavirin starting at 1200mg and reduced to 400mg at 3 weeks.

I also had past non-completion of interfeuron/Riba as it was awful.

I have heard fantastic news about the Daclatasvir med also.

The only medication that gave me problems was the Ribavirin, which is why it was reduced. It made me crazy nuts too with anxiety. Screaming with rage at Hubby quite a bit.

I had to take Valium with that to have control.

Wish you the best - you have a team working for you. Remember God is there for you also. I will keep you in prayers.
No one should have to ilve with this disease.

I am post treatment 14 months considered SVR or cured - find it hard to believe still.
Have great days and now having tummy problems. But I had the disease for almost 30 years.
God Bless and keep posting.

Many moons ago it seems, Daclatasvir and "Sovaldi" otherwise known as Sofosbuvir was being tested in clinical trials and was as good percentage wise or better than Harvoni. Because of the Greed that one of the 2 companies had - Daclatasvir from Bristol Myers, and Sofosbuvir now called "Sovaldi" from Gilead Sciences. The clinical trials were stopped because of the one company that does produce Harvoni which is a combination of Sofosbuvir(400mg) & Ledipasvir(90 mg). decided to pull out of the trials and any further cooperation with Bristol Myers. Whoops! I guess I spilled the beans on which company was the greedy one. :>)

We all would have had what Harvoni does today, many years ago but, because of the Greed from Gilead many of us had to suffer or died because of it. I mean they were 6 months prior to becoming approved! they already finished one of the required phase III trials. Bristol Meyers was willing to work something out with Gilead, but they refused by placing their bets on Ledipasvir to be combined with Sofosbuvir instead for FDA approval which took some more years to get it through all of the clinical trials necessary for FDA approval. Only on patients that had been in critical condition with less than 12 weeks to live were granted an open label treatment combination of Sofosbuvir & Daclatasivr..

There were two whom I read about. One was a liver transplant survivor, but was dying because the virus came back from dormancy to destroy his liver at a quicker pace than prior to his transplant when his immune system was stronger than afterwards. Needless to say the patient not only survived. He also cleared the virus in very short order and the damage to his liver stopped. The other one I don't remember much about it other than the fact that he also was a liver transplant survivor, and previously treated beforehand as well and he cleared too..

Greed Kills! That certainly was the case for many of us who could not get the original combination of Sofosbuvir & Daclatasvir

Thank you everyone for your responses. I appreciate your feed back. I have been super sick so do not have a lot of energy. Will journal tomorrow to catch up on what is going on. Again thanks and will try to give individual response se when not quiet so exhausted.

First of all I apologize for my horrible spelling typing. Sorry for difficulty reading it. My ribaravarin has been decreased due to anemia. Have gone through gambit of sx. Worse ones was depression and moodiness. I cried straight for 5 days. So thankful for understanding husband. URI sx even since bronchitis had resolved. Nausea and emesis daily. 5 more months to go. Oh I also now know what exhaustion really is. Was so exhausted I could hardly walk up ramp. Now I have 2 questions I don't expect any answers but does anyone else have these concerns.
1. Is it possible that non dectable only means it has hid it for just a certain amount of time. I just wonder. 2. The other concern/question is what are the long term effects of these meds. So many medications do not show the side affects until many many years later. Anyway these cross my mind frequently.

1.Go with what your doctor tells you. Is it possible it is only hiding...anything is possible. If your doctor says you are cured, run with it, don't over think it. That would be living in Fear. Life is tooo short for that.
2. Who knows what the long term collateral effects of treatment are? Many of these new drugs & drug combos are too new to know the answer. We DO know, that ridding the virus will cause more destruction. Does one want to avoid treating the hcv because of fear of the unknown? Not me, because I am confident hcv will eventually make me very sick, and it is negatively impacting my life NOW.

squeaker asked:
1. Is it possible that non dectable only means it has hid it for just a certain amount of time.
2. The other concern/question is what are the long term effects of these meds.

Trissa is right .. these meds are so new .. I dont think any one knows how our bodies will be affected down the road ,
I have done 3x TX and have no immune system left,am chronically anemic and my platelets are almost non existent ...,
I don't suppose I will ever really know if they are from the Riba ,Interferon ,or Sovaldi but I seem to manage ok and feel good for the age I am and the severe damage that the HCV wreaked on my body for 40 years.
Definitely better than before I took the Sovaldi Riba that I finished in Dec I As for it coming back ..its like the HC that i had .. No body knows if it will come back ..anything is possible ..
I can't live each dayin fear of what MIGHT happen ..I have to just enjoy each day as it comes

Try to just live each day the best you can ..worrying will not change the outcome ..LOL ( yes i worry terribly at times ) But I just try to enjoy each day
All the best

Hi,
I just want to share some info here with you all.

My father has HBV and his Viral account is more than 403,000,000 IU/ml. He tried interferon with other meds but didnt work out and poorly the side effects affect his personal life.

At this point we began to search other opportunity more seriously because his doctor had no other way to treat him.
To cut it short, we found a Japanese supplement called YHK. We were not really sure a supplement can offer something even medicine cant but we had a go.

My father took it for nearly 15 days and went back to check his ALT/AST and Viral, and amazingly his ALT/AST reduced to normal range within few days. No more inflammation in his liver, but the viral load was still bit hight.

This supplement seems to have many clinical studies and mainly for HCV patens. So I thought this might be can help any of you here.

My father didnt have any side effect while talking YHK and he feels much better now since. I think its safe enough and worth to try.
His doctor was really surprised and now only monitoring his liver condition regularly.

I had tried 2 tx cycles with no positive results. Both tx required stopping ribravarin due to low blood count. Actually had to get transfusions due to it. Started this tx of ribravarin, sofosbuvir, and Daclatasvir. Supposedly is best for genotype 3a and for HIV. Was anemic prior to starting tx. Spent the first month sicker then a dog. Pushed myself as I would like to get rid of viruses. Ended up hospitalin ed due to severe anemia. Bronchitis. Blockage and chest pain. Ribavirin was discontinued and no transfusions required. Interesting is I kept telling my HEPC specialist I thought coughing, nausea and emesis related medications. Or no it most likely something else. Interesting I was taking off ribaravarin when hospitalized. I felt like she was either wanted to play down side affects (so medications would continue to get good reports) interesting was have been off ribravarin for almost a week. Very little coughing, nausea improved and generally feeling so much better. Side affects despite provider making light of it I think so. There are so many potential side affects don't let your tx team make light of your concerns . Have to be honest and hope people understand. I did us some MJ tea and have actually desired food and able to eat without getting sick so you can decide for yourself if it was side affects. I have never been a promoted usage. After this week I can say it really has been medicallying appreciated. Hope this admission does not create negative attitude towards me. Will get off band wagan

Squeaker: You have to be honest - that is what we all ask for.

Most of us will say that the Ribavirin is nasty and some refuse to ever take it again.

I will never understand why some of the Specialists out there do NOT listen to their patients??

I was in the very FIRST group my Hepatologist started on Sovaldi, so he was VERY interested in what my side effects were.
I know I was a guinea pig, but my insurance was changing, so I knew it was then or never get the meds. It seems things have changed.
I know the darn price of the meds is ridiculous and maybe docs are now down playing comments so they can "improve" their scores - not sure.

I am grateful to God that I was in this first group, although terrified to be in it - it worked.

Just be honest, we as a group need it
Good luck to you and God Bless

so sorry to hear you are struggling. that riba is nasty stuff as i was on it for 24 weeks along with vikera pac.
the pharmacist told me it was for prolonging the fighting ability of the main hcv ingredient.
Because i suffered with insomnia, which the riba made worse, I cut back 1/3 after 12 weeks. I have been undetectable for 4 mnths and just got my 6 months test done.
I soo urge anyone contemplating the opportunity to get any of these new drugs to do it. I can tell you that for me i feel soo much better. i feel like my life is back. The little bit of discomfort of the riba soo outweighs the relief of having this awful virus out of my body.