GERD & Heartburn Support Group

Gastroesophageal Reflux Disease (GERD) is defined as chronic symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus. This is commonly due to transient or permanent changes in the barrier between the esophagus and the stomach. If you are afflicted with GERD or heartburn, join the group and find support.

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Gastrointestinal System
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Pepcid

nymima
nymima
I was just prescribed Pepcid 40 mg today for acid reflux. Is Pepcid considered a PPI? I know there is some kind of discussion about these meds in reference to kidney disease, esophageal cancer and even dementia. I don't know what to do now.
sptrout
sptrout
No, it is a H2-blocker, which was invented before PPIs. H2-blockers last about 12 hours, and some, if not all, brands can provide quick heartburn relief unlike PPIs that can take a day or two.

No idea how they compare to PPIs concerning all the recent news about the dangers of PPIs. I would not want to take either longterm.
nymima
nymima
Silly question - but does one "graduate" to a PPI after being on Pepcid for a while?
sptrout
sptrout
I really don't know. They work differently and it seems that doctors only prescribe PPIs. I didn't know that H2-blockers were available for Rx since they have been OTC for years.
nymima
nymima
The only thing I can think of is that the doctor wants me on 40 mg. of Pepcid. Maybe OTC Pepcid only goes up to 20 mg? Not sure.
sptrout
sptrout
You are probably correct in your dosage assumption. The next time you see your doctor ask why a H2-blocker instead of a PPI. Would be interesting if side effect issues is the reason.
Lesleygm
Lesleygm
It is better to start off with Zantac or Pepcid. They dont have the same long term side effects as a PPI does.

I prefer Zantac. I am pretty sure it works better than Pepcid but it is good to see a doctor that starts out with this type of acid suppression for a change.

Being on a PPI does not cause esophageal cancer. Having chronic relfux can lead to barretts esophagus and then it can become esophageal cancer. Kidney disease and bone loss are the most common potential problems with acid suppression. More so with a PPI.

Acid suppression over the long term using a PPI or Zantac etc is not wise but Zantac and Pepcid are considered safer.

This issue is managed best with a careful diet and managing anxiety and any mental health issues. Anxiety can cause reflux regularly.

Reflux problems are most often caused by lifestyle and or a mechanical problem like a hiatal hernnia.