I recommend tappering. I made this stupid mistake before of not tappering my gastritis got really bad but struggled to get it under control and did further damage but it may not be the same for you.

I stared with nexium worked good..im on Prilosec 40 mg aday..I think there pretty much the same. Good luck with zanac

I would taper for a few weeks. You'll go from making pretty much no stomach acid on the PPI to making some on zantac, so there will be the possibility of some rebound if you do it too fast. I'm sure some others will have some more information for you

I'm looking at switching from Omeprazole (40mg) to Zantac soon.

How exactly should one taper off? Go from 40mg every day to 20mg every day for, what, a week? Then 20mg every other day for a week? Then switch to Zantac?

Just want to know what's worked for others.

Don't switch off right away!! nonono. If you read the pharmacology report for Prilosec (in my case it's Dexilant), you'll see that the PPI works to stop the process of gastrin (the hormone released by your stomach) from stimulating acid secretion. The problem is that the gastrin then accumulates in the blood, and when you quit cold turkey, that gastrin will react and you will have massive acid rebound. It's very real, and can last for up to a month before gastrin levels go back to normal. It's likely that NOBODY will tell you this.

I previously went off cold turkey, and like GuskoBurido, it did horrible damage - it took me months and months to figure out what happened, because I went from minor issues, to feeling "healed", to not being able to walk because of the pain in a matter of 1 month.

Neither my doctor, nor the pharmacy told me not to quit cold turkey. I went back to my old lifestyle right away, drank coffee, went out for Vietnamese food, all while something felt terribly new and wrong. I had massive acid rebound that caused me a whole new world of damage and problems.

I'm now too scared to taper and not even sure if it's possible to do. I do feel better, but I don't know if it's because I'm actually better, or the PPI just masks the issue. I am forever putting off the tapering from my PPI, because I'm too scared.

My doc and I laid out this plan:

First 2 weeks: Alternate 60mg and 30mg, plus 300mg Zantac in the evening when I take the lower dose (if needed)

After 2 weeks, 30mg/day for 1 month, plus the Zantac, if needed

After that, I can alternate 30mg and Zantac.

Starting next week I'm going to go from 40mg a day to 30 for two weeks and 150 Zantac at night, then do 20mg a day with Zantac at night for about a month and then switch to every other day with prilosec for about two weeks and then every three days after that, all with Zantac at night. Hopefully this works. Once I'm completely off I'm still going to lay off trigger foods for about a month, and then start introducing things back in my diet.