I hope there is someone with some advice for me. Here's the story. I was taking a nutritional supplement that helped me really well with the fatigue and pain. Then a bout of depression sank it, so I started Cymbalta. Then I had to go off the supplements. I was then told I had mono, was really sick for two weeks. Got a sinus infection. Doc put me on Elavil to add to my flexeril I take every night anyway, for sleep. I know this is choppy, sorry. Anyway, I have put on ten pounds in the last two months, and am continuing to gain. All this weight since the Cymbalta and Elavil were added. Yes, I had struggled with my weight before, but I was on a downward trend, now I am upward and not stopping anywhere. I have read that some people gain weight with Cymbalta, so this is what I want to stop, but my depression was sooo bad! What do I ask for in place of it? I can't take Welbutrin, tried that, Celexa, Prozac, Paxil, and Effexor. Most either made me gain weight or made me too uncomfortable (rapid heart rate, feeling like I can't breathe). I feel stuck! Thanks for any replies. Julie