I don't mind sharing my experience if it may help someone else. Everyone reacts differently to medications so it's hard to tell what will work for who.

I am currently taking Cymbalta, and Tramacet (Tramadol combined with acetominiphen) for Fibro. I initially tried Cymbalta on it's own, however it did not help me with muscle pain or fatigue. It has helped with brain fog, anxiety and sleep though. Since the Dr. added Tramacet, I find that the "volume" on the pain has been turned down if that makes sense. I am still in pain, I don't think there is anything that will take that away. BUT I can concentrate a little better and find I have a bit more energy. I do feel like it is false energy though, as when it wears off I go back to feeling like I am dying unfortunately.

Other things I have found to help are warm water aquatic exercise and massage, although they only provide very temporary relief.

I am not on any medications for the fibro b/c I'm on meds for my OCD and they are pretty much the same type of med. I have started taking Diatomaceous earth which is a naturally occurring substance in the ground which is supposed to have great benefits to the human body. It is 85% silica which the body needs down to the cellular level and even though I have only been on it for 6 days I do feel a bit of a difference. I started taking a lower amount than what I read about b/c I was uncertain what it would do but I am going to up the amount tomorrow b/c I have had no side effects. If you are interested you can buy it at most health food stores or online just make sure that you buy FOOD GRADE b/c that means it has been prepared for ingestion purposes. You can read up on it online if you like first....that is what I did. earthworkshealth.com has good info on it and tons of testimonials if you would like more info. Hope this helps you.

I take Cymbalta, Tramasol ER 200mg, Oxycodone 10mg 2x a day. I also take a lot of vitamins. I have tried Flexeral, Gabapentin, and Topomax. None really helped so I stopped taking them. Narcotics are what works best for me. I hate taking narcotics daily but it makes me functional. I tried to go off of them for 3 months and i was miserable. Way to much pain!

I can't take anti-depressants so Savella is out. Tried Cymbalta---yuck.

What is my mainstay is 2.5 mg of methadone for pain daily + a baclofen 5 mg with it.

At night for sleep, trazodone, 25 mg. Been on those forever and I have a life. Sometimes the pain gets really bad and I use clonazepam 2.5 mg or tizanidine (another muscle relaxant).

On a daily basis I use Bengay, capsaicin cream (works well), heating pad, cold packs, walking, distractions like Netflix, music, positive thinking.

Good luck. Keep trying out different things and stay hopeful!