I have tried Guaifenesin off and on, but I didn't do the whole protocol. It does help a little bit especially if you have allergies, sinus problems.

I take it with my sudafed during my allergy seasons,helps me from getting sinus infection. I havent notice it helped with pain.

Maybe someone else has some positive info.

I recently had a cold or the flu and started taking it. I noticed that my Fibro was much better. Now I take it bedtime I really think it helps, but didn't know if it was all in my mind until I read your post. Thanks. More proof that I'm not crazy. lol

When I was first diagnosed, I bought the book regarding curing Fibro with the guafenisesin protocol, if that is what you are referring to. I thought that I could follow it and be back to work in a couple months.

It said that you feel worse at first and then get better....my personal experience was that it was HELL!! My pain and fatigue went from debillitating to paralyzing and I was bedridden for a year. I tried to do exactly as it said and after one month, gave up.

I don't know if it has worked for others, but it was horrible for me.

Pain...not really.

Let me explain. For me, Guifenesin, turns into energy. The more energy I have the less pain I have. Which is usually our double edge sword. Low energy - increased pain levels.

I typically take this intermittently to help with my fatigue spells.
Doesn't always do the trick, but there are days where it's like taking a 4hr energy pill.

Wish I could do the chemical breakdown for you, but I can't. I just know it works for me. And I'm thrilled that there is something I can take as my list of "can't takes" is longer than tomorrow!

Has o effect on me beyond loosening my mucus. But if it helps, hey, it helps... no predicting what might with FM!

I have also read the book recommending this, have not tried it but I do know it is one of the safest meds around. They used to prescribe it for my sinus infections years ago-worked really well. I still use it for the sinus otc mucinex.