Some people don't have good results with medication. I'm very sensitive to medication and can take low doses of some things or in many cases not at all. Some folks find nothing helps them.
There is a wearable medical device called Quell that works for 81% of the people who try it. It is not for migraines. It is not covered by insurance and is $250. Here is the link: https://www.quellrelief.com/ I've had mine since it first hit the market and found it to be very helpful. There are other options including acupuncture, massage, dry needling and classes for people with chronic pain so they can learn coping mechanisms. Take care.

I'm still trying to find what works for me. I can't take the usual medicines - Cymbalta, Savella, Gabapentin, and now Lyrica. I'm weening off Lyrica because it made me feel so doped up, but it did help with the pain. I saw a Rheumatologist who just started me on new medicines that shouldn't have many side-effects - Limbrel and Rheumate. I just started them so they haven't kicked in yet. I just hope they help. I've also had acupuncture which really helped, but can't afford it now. I also need to do more yoga. It really helps me when I can do it regularly. I hope you find what works for you.

Susan

As with any condition, fibro meds may work or not work or stop working after they did work and so forth. As Fantod said, I try non-medication options, and so on. The one class of drugs that really gave me relief? They took off the market forever. *sigh* Figures!

I doubt there is any medicine for anything that works for everyone but I will give you info on one that is working wonders for many. It is called Naltrexone and is a generic med and is off label use for MS, Crones, and FM so your insurance probably won't pay but it only costs about $45/month. It is getting good results for many and totally worth a try. It must be made up in small doses, start one month at 1.5 mg. one month at 3.0 mg and finally maintenance dose of 4.5 mg. I noticed improvement within about two weeks of starting the 3.0 dose. It seems to work on many FM symptoms, not just pain and exhaustion. Must be made by a compounding pharmacy (no big deal if you haven't used one before) because the drug companies only make it in 50 mg doses, way too much for our purposes and they can't make money on it at smaller doses because it is now generic. I really urge all FM patients to give it a try. I have struggled with FM all my life and am now 68! Naltrexone is the best help I have found! Ann99

One more thing. Over the years I have tried all the other supposed FM meds, including Lyrica etc. etc. None worked because of extreme side effects. Most FM people are highly sensitive to drugs! With Naltrexone, though, it is such a tiny dose that I have experienced no side effects at all, and heard the same experience from others. Please do give it a try!

Thank you all so much for the feedback. I have done acupuncture before and it didn't help, but it did help my anxiety. Im going to a special hospital soon so hopefully they can help me function and get bacm to school but i dont want to get my hopes up anymore.

I'm bipolar and a lot of the meds either don't work or mess with the psych meds so my Dr and I have been looking at holistic ways of treating it for quite some time.

Greetings, I am 68 years old and have had FM since teen years and before. I have tried all the FM meds and all had too severe of side effects for me to stay on them. Everyone I know has gained about 10 lbs of weight every month they were on Lyrica! I did too. It went away after I went off it. I am now on a different kind of med called Naltrexone. Old generic drug now being used for MS, Crones and FM. You must get it from a compounding pharmacy due to the small dose used and not covered by my insurance but only $45/month. Start with 1.5 mg for one month, then 3.0 mg for one month, then 4.5 mg maintenance dose. With such small doses, I have not heard of anyone having any side effects at all! Now, that's a good medication! I noticed a significant difference in all FM symptoms, not just pain and exhaustion after about two weeks on the 3.0 mg dose. It is supposed to help you to keep improving for 12 to 18 months and then level out. Working well for me at about 6 month mark. Find a Neurologist who is a specialist in FM, not a Rheumatologist (wrong direction); and most neurologists don't have a clue about FM but the ones that do can be helpful. Current research indicates that FM is a disorder of the nervous system, not a muscle or joint issue. The right kind of message helps me a lot also. Moderate activity always helps. You will probably have more pain lying around than doing what you can, just don't overdo as you will pay dearly the next day. FM is very fickle; really bad one day, week, month or year and much better the next, etc. so is kind of a wild ride. But, you can still do many things if you stay flexible, stay positive and listen to your body but don't let your body boss you around too much. Good luck and try the Naltrexone!