Depression Support Group
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Confusion or another type of psychosis is a pretty rare side effect. You should make sure it's not interacting with some other medication he might be taking for something else; call your pharmacy if you're not sure.
If the strange behavior and strange feelings have been constant or started before he started the prescription, it could be something else, but if everything started at the same time as the Wellbutrin and things have gotten worse, then it sounds like that would be the meds. There are soooo many types of anti-depressants so your husband's doctor might ask him to try a different one.
Could you describe his behaviors/symptoms a little more? Does he seem either "sped up" or slowed down in the way he moves and speaks? How is he sleeping? How is appetite? etc
Speaking from my personal experience, wellbutrin was very easy to take and didn't have a lot of the typical side effects like nausea, headache, or dry mouth. I also took it in combination with another med to augment the effects and it just acted as a sedative pretty much, so it wasn't the right one for me, and my doctor switched things again.