yes or maybe you need your dosage upped. I would call my dr as soon as I could and talk to them about it.

Yes. Anti-depressants absolutely can and do stop working. Anywhere from six months to up to two years for me then I have to switch. Sometimes taking a "drug holiday" for a couple of weeks helps too. Check with your doctor.

They can stop working.

Yes. It's trial and error. My meds have quit working in the past and then we start over from square one. It's a drag but once you find the right meds, it makes all the difference. Keep the faith! :)

All the time! Meds never remain same for long. Have been on meds 12 years and they change from weekly to monthly (I have been on dozens). Tweaking a "med cocktail" is very common with mental illness because it's trial and error.

please take this seriously, lovebug. i took paxil for anxiety, and despite the fact that i upped the dosage 4 times in 4 years, it wasn't working. i got really depressed and started self-injuring. i went to my psychiatrist, and did he give me new meds? no, he just upped the dosage again. i was in HELL for three more months before i finally got him to start me on effexor. please take action.

I was on celexa for 4 years and I had a major upset in my life and it stopped working. Upping it didn't help so now my dr. has added Wellbutrin to it. I am praying it works.

My doctor and I increased my dose of venlafaxine from 75mg to 150mg daily a few months ago. I felt very little difference. I have been on 225mg a day for the past few weeks now. I can tell there is a difference, but I'm still struggling.

There are so many options, including adding a medication that works alongside your current med.

I'm going to keep going until I find the right combination. It's worth it. You are worth it.

Absolutely, YES! I was on Pamelor for NINE YEARS and it worked fine. Then. . .it just didn't any more. My shrink said it was because of menopause. I didn't feel like discussing gynecological issues with him, but I had already been surgically menopausal for several years.

We tried a few other anti-depressants and they didn't work, so I just gave up. Reading back over my journal for the last couple of years, I realize that I haven't really been totally alive (or even much interested in being alive at all in spite of having a pretty decent life) for a long time, so maybe it's time to look into one again.

With the health system in such a state of insane flux, I have been reluctant to get started on ANY more drugs, for ANY reason, but I might make an exception.

My adult son and I are chemically alike in many ways, and he had a really positive response to Cymbalta, so I'm wondering if I ought to try that. Has anybody else had experience with it?

Yes; my daughter has had to change meds or add something. Maybe a mood stabilizer w/ anti=depressant or an anti-anxiety pill. hugs...AG

Yes I've had that happen.

Yes I've had this happen. One time it was overnight, I was fine one day and completely miserable the next.
You have to keep trying, don't give up!

Meds can lose their potency - God, I hate antidepressants, but sometimes they can help people a lot. What does your doc say?