from what i have read here and on other sites, daliresp seems to either work great or not at all for people.
It sounds like it wasn't a good one for you.
I hope your dr finds something that works for you.

Daliresp.has bad side effects...and is costly...a pulmonary dr. said Nac works just as well with no really bad side effects....its true it works well on some people and not so well for others...

I ran across this video while researching something else. It was of interest to me because I was put on Daliresp for about a month and the depression was overwhelming so the doctor stopped it.

https://www.youtube.com/watch?v=adN8VeJFe8A

I hope not to alarm anyone unnecessarily but if you are on this drug, please watch the video.

I was on Daliresp previously about a year or so ago for a period of about six weeks and ended up gradually sinking into the horrible depression everyone has mentioned and was actively planning my exit, going so far as to how to take my dogs with me. I stopped it on my own after about a month or so. I seem to recall gradually improving but a few months afterwards it almost seemed like I bounced back to where I was on the Daliresp and asked my doctor to increase the dose of antidepressant (Paxil) I was on, which he did. I'm not sure he believed it the depression was from the Daliresp, but I think he's one of those doctors that is content for me to tell him what I want to do and then he humors me.

Recently I saw a pulmonologist and she asked me to try the Daliresp again (which I am on in addition to high-dose NAC). I did explain to her the trouble I had with it before. She told me to keep a close eye on my mental state, thinking that as long as I am closely self-monitoring (which obviously I knew enough to hit the brakes last time, no reason for me not to do it again), and believes that it's worth a longer trial to see what benefit I get from it, and if necessary we can increase my Paxil as I still have a lot of room to go up on that. It's worth noting that my primary care does not believe in that strategy at all, would prefer I not take it at all (so now he's suddenly a believer!), but at the very least at the soonest hint of sinking mood dump the Daliresp.

I will say at this time that after a month, I'm not feeling anything more than what seem like appropriate Debby Downer moments as would be expected. I can't say, though, that I'm feeling particularly better, although my understanding is that it isn't so much supposed to improve symptoms, but more to prevent frequent exacerbations/attacks, and it may be too early to judge whether it will do that.

Long story just a little bit longer, if it's the depression that is getting you and still has not lifted (or any other symptom for that matter), do not hesitate to ask a doctor to either increase or add an antidepressant. There is no need to suffer more than we already do so you might as well relieve any symptoms you can. And for those interested in trying it, maybe the key is to have an antidepressant on-board and ready to be increased at the same time you start it.

I was on Dailresp for 10 months. I was dizzy and could not focus on anything for all of those 10 months. Plus I lost 40 LBS. I was put on it after an exacerbation that was long and hard to get over. Since it has now been 13 months since I quit daliresp and 25 months since that bad exacerbation, I can say that I did not benefit from taking it at all.

I have to agree with jarca - Daliresp was presented to me as a medication to help limit exasperations. That's all. And it has done so very, very well, With, for me, zero bad effects. It's costly, yes. And, because it was expensive, I stopped it for a while. And didn't do as well. So, for me, it's well worth the money. Thanks to finding ADC for my other more expensive meds (Advair, Spiriva versions), I'm back to buying it every month.