Your complaint is the number one reason people stop taking Daliresp (Second, the side-effects). However, it is not a wise one. Daliresp is unlike any other COPD medicine currently available.

Daliresp has been demonstrated to not only help reduce frequent exacerbations you may be experiencing now, but to ALSO reduce the risk and severity of FUTURE exacerbations. A common analogy is lower blood pressure and cholesterol medications you dont feel or notice them working, but they are. Once you start and you can tolerate Daliresp you need to keep taking it daily. Also consider it is not fully effective until you have been on daily maintenance for weeks.

If you still intend to stop taking Daliresp you need to inform your doctor.

you might have misread my post i think the new medicine is great i dont think nac did anything for me

glad to hear you found a med one that helps. how long have you been on it now?

LOL! I did misread your post, but I had help. I hollered over to my daughter and asked what nac meant in net-slang she said Not A Chance.

Gnott..isn't that for bronchital type emphesema.?? .those that cough and have sputum issues....for us other guys we must not take it.....those who never cough....

Im not aware of any restriction or limitation based on coughing, but Im not a doctor. Its my understanding it controls inflammation, and by reducing inflammation it reduces the likelihood, frequency, and severity of exacerbations. It is unlike most of our medications as it is NOT symptom specific, but there is a fine-line to be drawn here since inflammation can lead to exacerbations that consist of coughing, sinus drip, constricted breathing, extra mucus etc. And of course one might develop these symptoms, yet not necessarily be deemed inflamed.

In other words, the key to a prescription is whether a doctor determines that you are currently having frequent exacerbations or flare-ups, or at risk to have severe exacerbations, due to inflammation that otherwise isnt or cant be managed. This is important because on the long road of progressive decline it is the very fact of having an exacerbation that does the most damage and must be avoided. Treating the symptoms and getting one back on their feet and going again is less useful, because the damage has already been done.
Here is more detail:
http://www.thinkcopdifferently.com/Think-COPDifferently

Thanks Gnott..the main thing is to stop frequent exacerbations....This is why im doing week 20 out of a 60 week Clinical Trial..

https://clinicaltrials.gov/ct2/show/NCT02105961

Dang, once again I miss the ability in this forum to edit a post.
I forgot to add that you are correct in that there is a direct relationship between inflammation and increased sputum production (coughing), and there is direct relationship between increased sputum (coughing) and increased frequency of exacerbations. Thus a lack of a consistent cough could be considered a sign that inflammation is not a major issue. However, I believe it is going too far to suggest that if you dont cough you shouldnt take Daliresp. After all, if one suffers from COPD a sudden onslaught of inflammation is always just around the corner. Smile.

Daliresp is for those who have frequent exacerbations, but it is totally up to ones doctor (who has far more information about ones medical condition and history) to determine if Daliresp should be prescribed.

daliresp is costly and nac is not....and my pulmo says nac works just as well as daliresp...sooooooooo toss a coin on this one folks,

Peter= ty for sharing the link on the trial you are doing....lots of info to read, but fascinating.
---it says it is a "sub-q" injection;
but, you mentioned a shot in the back of your leg that takes 20 minutes?

ya got me interested in the "delivery method" --- are you allowed to tell more about it?
as i am really curious about the injection part as if it comes to market that sounds pretty tough to do.

also, do you feel any better or worse with the treatments yet?

amazing stuff;
thank you for devoting yourself to "be studied"; hopefully it will help others someday!

Usually its in the back of arm but I have trouble finding a vein...so back of leg...it might be less time but it seems longer cos the needle is in for ages it seems..

no..i think I might be on placebo...HOPE NOT...

if you pass the trial then they will continue the treatment even before it becomes available or so they tell me..one needle a month..

qwapo,
oh my you are a braver soul than i am!!!
needles scare me, but if it actually helps i guess even i would go thru that every month.
the info in the link said it was "sub-q", but it's in a vein!?!

if you are in the placebo group, will they let you have "the real stuff" if you pass the trial?
free meds is a plus also :)

(sorry for the "quiz", but this is so interesting! i have never known anyone that did an actual trial like you are)

Yes.....they will select those that they feel will benefit, not sure what that means, but my pulmo is the one doing the Oz trial and im sure he will give it to me...i'd rather him discuss the coils or transplant than anything else, but he is very evasive there lol....

I HATE NEEDLES..believe me....