I've had an immunoglobulin panel test a few years ago and was diagnosed with hypogammaglobulinemia. I have low IGg-across all sub-categories. I had years of battling bronchitis and finally got my tonsils out at 21. I am now 36. I had to get my immunity for Hep B checked for school and showed no immunity so they did a booster and still no immunity so my doctor had to write a letter explaining that I would probably not ever have immunity. Recently in the past year I have suffered from numerous sinus infections and a MRSA skin infection that lasted 4 months and required 4 antibiotics and Zyvox twice over a two month period to get it under control. I have recently over the past several months been sleeping and exhausted a lot. I come home from work and sleep 1-2 hours wake up and eat dinner and then take my nightly meds and go back to sleep between 8:30-10pm. I sleep until after 7am and I'm still tired. I am going to see my Hemotologist/Oncologist next week because I've had a productive cough and lots of congestion and green mucous from my nose over the past couple/few weeks. I want to have my immunoglobulins checked again (I think the overall level was 526 2-3 years ago). I've read that numerous respiratory, skin, bacterial infections can be problems associated with Hypogammaglobulinemia. What I am wondering is do our levels continue to decrease over time and with these recurring infection should I push for IVIG? My Infectious Disease doctor who handled the MRSA infection was concerned that I had not had any follow-up in years for the low IGg. A few years ago I had a hysterectomy and had a standing order from the Hem/Onc for IVIG if there was any indication of infection, but they did not give it to me because luckely I had no problems. Is there a certain level that is needed to warrant IVIG or is symptoms and low IGg enough? I am in the medical field but wanted to find out what you guys think. Would the IVIG help the fatigue as well as the infections or do you seem to notice a difference in energy levels after infusion?

Thanks for all of your replies and support. I have learned a tremendous amount from this group in the past few months.