Bipolar Disorder Support Group
Bipolar disorder is not just a single disorder, but a category of mood disorders marked by periods of abnormally high energy and euphoria, often accompanied by bouts of clinical depression. This is the place to talk about your experience with bipolar disorder, learn from others' experiences, and find support.


Be careful with the benadryl. It's an SSRI believe it or not so it can mess with you serotonin levels. Until about 4-5 months ago, I had been using it frequently as a tranquilizer because the only sedative they will give me now is hydroxyzine and that's basically a very long-acting benadryl. Would zonk me for over the whole day when I could count on 4-6 hours at most for the benadryl. Sometimes took 3-4 pills to do the trick and it always would, but I noticed I was less stable overall. I also realized that if I was needing to take that much beny, I wasn't taking enough of my oxcarbazepine or I shouldn't need that much assistance calming the mania. There shouldn't have been that much mania.
But yeah I forgot about the hand tremors from the lithium. Don't recall if it was anywhere else on my body but I stopped taking it after 2 or so months. The kidney thing is scary.
Recreational users report calming effects, mild euphoria, and hallucinations as the desired effects of the drug. Research has shown that antimuscarinic agents, such as diphenhydramine, "may have antidepressant and mood-elevating properties".
This is why docs prescribe hydroxyzine instead of diphenhydramine for anxiety when they are, and act, very similar and yet the latter is available OTC and very inexpensive.
Anytime you see the term "antimuscarinic" just know that it comes from the term "muscarine" which is a psychoactive (and anticholinergic) chemical first found in certain mushrooms - the most notable being the famous white spotted red cap Toadstool mushroom we in countless paintings and other art forms across the world (Alice in Wonderland for one).
Benadryl (Diphenhydramine) does not have negative interactions with all SSRI Antidepressants, there is actually very little data to support these claims. The 1 drug that does have research and proof of a negative interaction is Zoloft.
But, Benadryl (Diphenhydramine) is not classified as an SSRI, its an Antihistamine. Its also used to counteract withdrawal symptoms from SSRI Antidepressants in some patients. And some Antihistamines such as Vistaril are used as Anti-Anxiety medications.
Diphenhydramine is not generally advised to take long term as it can cause Cognitive impairment.