Atrial Fibrillation (AFib) Support Group
Atrial fibrillation (AF or afib) is an abnormal heart rhythm (cardiac arrhythmia) which involves the two small, upper heart chambers (the atria). Heart beats in a normal heart begin after electricity generated in the atria by the sinoatrial node spread through the heart and cause contraction of the heart muscle and pumping of blood.
What you were experiencing while on the Amlodipine is called a vasodilatory edema. It is a very common side effect of vasodilators, such as direct vasodilators, calcium channel blockers, alpha blockers and antiadrenergic meds. This type of edema is caused by arteriolar dilation, an increase in the stimulation of the renin-angiotensin-aldosterone system, and, of course, fluid retention. It is dose-dependent, which means that the likelihood of these types of problems increases with the dose. They say that if an ACE inhibitor is added to a small dose of a CCB, the incidence and severity of edema is greatly reduced. It does not seem to work for me though, probably because my doses are high.
Call your doctor. You might need to switch meds. What meds are you on?