Atrial Fibrillation (AFib) Support Group
Atrial fibrillation (AF or afib) is an abnormal heart rhythm (cardiac arrhythmia) which involves the two small, upper heart chambers (the atria). Heart beats in a normal heart begin after electricity generated in the atria by the sinoatrial node spread through the heart and cause contraction of the heart muscle and pumping of blood.
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In research by Mesoblast Ltd. (MSB), 45 patients who had moderate to severe congestive heart failure were given a shot of the Revascor treatment and standard medicines, while 15 didnt receive the experimental drug. The therapy was safe and well- tolerated at all doses, according to results of the Phase II study presented yesterday at an American Heart Association meeting in Orlando, Florida.
Mesoblast said it expects to enter Phase III trials in the first half of next year. Revascor may begin making a profit for the Melbourne-based company by 2015, when the treatment is expected to go on sale, David Stanton and Zara Lyons, analysts at Nomura Holdings Inc., wrote in a Nov. 4 note.
The data was outstanding, Stuart Roberts, an analyst at Bell Potter Securities Ltd. in Sydney, said by telephone today. This is probably the biggest thing in heart failure in 10 years.
Heart Pumping Ability
Those given the lowest dose showed a significant improvement over three months in ejection fraction, with a sustained but less pronounced effect over 12 months.