Not on Effexor, but I did when I was tried on Celexa some years back. Agitated, short temper, was hard to maintain attention span. Doc said it would go away, but two weeks later I had had enough of tapping my foot constantly, lol. Effexor is different It is a SNRI, not a SSRI. It acts in a similar manner as a SSRI, but Effexor works on norepinephrine(noradrenaline) as well as serotonin. Personally, and a few docs I know agree, Effexor and other SNRIs are not the best for anxiety, because it not only stimulates serotonin, but norepinephrine as well, one the fight/flight response catecholamines released by the adrenal medulla(adrenal glands) during anxiety and panic, though it is widely prescribed for GAD. You actually want norepinephrine toned down in those with anxiety, as it is this catecholamine that gets the heart racing, the palms sweating, the stomach upset, racing thoughts, elevated bp, etc. It can also cause anger and agitation through stimulation of these catecholamines. XR is the extended release version. Effexor is more effective where there is depression. Depressed patients have a better response to norepinephrine stimulation than anxiety patients, however some anxiety patients respond well to Effexor when the anxiety is accompanied by depression that occurs with agoraphobia or severe social anxiety. Hope this helps. Take care.

I just came off effexor because it made me suicidal. at first it would give me terrible headaches, then made me like cataonic, then the suicidal thoughts came, scared the shit out of me!

yes angry to the core...personality changed. i divorced a great guy, as you see it made me very extremely manic...and then depressed....the withdrawals were the worst....BUT IT DOES WORK FOR SOME...just read all you can so you know what can happen....there is a web site that people share.......google " petitiononline.com/effexor...
there is a full discription, then people sign in....about 25,000 signitures and they tell there experiences....good luck, I hope it works for you....just my experience was not good...i was on it for 8 years..did not now what it was doing....cause i did not care....

i was on effexor for four years and it worked great.... i liked it a lot.

I was on Effexor and I turned into a complete monster. You never knew what would send me over the edge. It freaked me out when I threw my x who was 5'11 and 330lbs across the room ( & I'm 5'2 @ 190 @ the time) needless to say I stopped taking right away. When I called my Dr. he agreed. Good luck!