Acromegaly Support Group

Acromegaly (from Greek akros "high" and megas "large" - extremities enlargement) is a hormonal disorder that results when the pituitary gland produces excess growth hormone (hGH). Acromegaly most commonly affects middle-aged adults and can result in serious illness and premature death. Join the group to discuss symptoms, diagnosis, and treatments.

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Endocrine System
/ Acromegaly Support Group

Sandostatin and Tamoxifen treatment?

carebear1022
carebear1022
I was wondering if anyone has used both sandostatin and tamoxifen (breast cancer drug) to treat acromegaly? It has been shown effective in lowering Igf-1 and GH levels in women. Thought it may be an option for those of us who the standard treatment ineffective.


http://www.ncbi.nlm.nih.gov/m/pubmed/9364247/

http://www.ncbi.nlm.nih.gov/m/pubmed/21221819/
carebear1022
carebear1022
http://www.ncbi.nlm.nih.gov/m/pubmed/12656665/?i=6&from=/9364247/related

Here is another study where tamoxifen was used alone for treatment of acromegaly when the patient was unable to tolerate other treatments such as sandostatin. I wonder why it is not being used more often?
carebear1022
carebear1022
Sorry the last study was using a similar drug to tamoxifen called Raloxifene.
carebear1022
carebear1022
Here is another study with hormone pills that has been shown effective

http://www.ncbi.nlm.nih.gov/m/pubmed/12841543/
carebear1022
carebear1022
Sorry last thing:

Selective estrogen receptor modulators (SERMs) like tamoxifen and raloxifene have been shown to reduce IGF-I in small series of acromegalic patients. Tamoxifen was able to normalize IGF-I in 31% (4/13) of the patients (males and females) and raloxifene in 54% (7/13) of the female and 25% (2/8) of the male patients (49-51). Also, estroprogestinic pill has been shown to normalize IGF-I levels in 50% (4/8) of the female patients (52).

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302005000500004