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Although a formal test of interaction (sex*originality) was not significant, this result suggests that associations between precuneus rGMV and ideational originality tend to be more strongly driven by the female population. While the finding should be interpreted with great care (because of the rather small male subsample in this study), it points to the importance to consider sex as an important factor in http://www.selleckchem.com/products/DAPT-GSI-IX.html future studies. The choice of the method used to correct for multiple comparisons is a crucial question in MRI research (Woo et al., 2014). We corrected for multiple comparisons by means of 3dClustSim, which estimates a random field of noise in a given voxel space that serves as the null distribution for significance tests. By this means, it is possible to obtain the minimum size of (true positive, non-noise) clusters at given voxelwise (p? http://en.wikipedia.org/wiki/NK_cells of low intensity ( Smith and Nichols, 2009). Thus, we additionally examined the effect of TFCE correction to our main analysis (effects of creative potential; full sample). 3 The obtained results pattern was similar, but for TFCE not significant (clusters in precuneus and striatum were only observed at FWE-corrected p-values of .08 for the precuneus, .12 for the striatum). We conclude that the TFCE method seems to be more conservative. It should be noted, however, that the precuneus effect was previously reported in three out of four VBM studies of verbal creative potential. This consistency of findings strongly suggests that this finding represents a true positive result (in terms of signal detection). This study investigated http://www.selleckchem.com/products/Gefitinib.html brain structural correlates of different facets of creative potential. We used latent measures of ideational fluency and ideational originality considering the influence of intelligence and openness. We found that originality draws upon regional gray matter volume in striatal regions as well as in the precuneus. The association with striatal regions might point to the role of the dopaminergic system in creative cognition, which foster exploratory behavior in terms of novelty-seeking and might thus lead to the development of a large corpus of experiences and knowledge. The association with the precuneus may be related to a higher proneness toward internally directed attention and mental simulation processes in creative individuals.