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7��10?3 (data not shown), suggesting the possibility of multiple functional variants within the region. In addition to the well-established http://www.selleckchem.com/products/Adriamycin.html SLC2A9 region, five other potentially significant regions (Table 1) were identified with at least one SNP above a threshold of P http://www.selleckchem.com/PD-1-PD-L1.html variant, showing the highest signal (P= 5.14��10?6) is a nonsynonymous SNP (rs2231142, NP_004818.2, Gln141Lys) and the mutant allele associated with an average increase of 27.40 ��mol/L (Supplementary Fig. S3). This SNP showed significant gender-specific effects, with 31.11 ��mol/L in males compared to 22.97 ��mol/L in females. Reanalysis conditional on this SNP explained all the association across the region, which is highly suggestive of this missense variant being the functional SNP at the ABCG2 locus. To compare our findings with previous GWA studies, we analyzed 30 serum urate- or uric-acid-associated SNPs listed in the GWA catalog (six of the 36 reported SNPs were missing from our imputed and cleaned data set) (Table 2). In addition to the aforementioned SLC2A9 and ABCG2 loci, we replicated associations with nominal significance (P http://www.selleck.cn/products/MK-1775.html by including all samples. Previous study indicated that GC is a valid and powerful method for the analysis of pedigree-based quantitative trait loci (Amin et al., 2007). The most significant associations emerged from multiple SNPs in and around SLC2A9 on chromosome 4, a widely replicated SUA-associated region. The SNP with the strongest signal, rs13129697, is located in intron 7 of the gene. Of particular interest, however, was the association of rs16890979 (Val253Ile), a nonsynonymous imputed SNP that has been reported in previous GWAS (Dehghan et al., 2008; McArdle et al., 2008).