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023, 95% CI: 1.010�C1.037, P?=?0.001) per 1% increase in the percentage of pretreatment PC and BCP mutants, respectively, after adjustment for other predictors. However, only the pretreatment percentage of PC mutations was significantly associated with HBeAg seroconversion when HBV DNA http://www.selleckchem.com/products/ch5424802.html sustained decline in qHBsAg in HBeAg-positive patients. Patients with HBeAg loss and HBV DNA http://www.selleck.cn/products/Everolimus(RAD001).html compared with a prediction-rule that used HBsAg levels of 20?000?IU/ml to identify patients with high and low probabilities of response. These results showed that nearly all patients with HBsAg >20?000?IU/mL at week 24 failed to achieve a response, whatever the HBV genotype (Negative predictive http://www.selleckchem.com/products/azd9291.html value for response and HBsAg loss was 99 and 100%, respectively). Therefore, qHBsAg is a strong predictor of response to PEG-IFN in HBeAg-positive CHB. Treatment discontinuation is indicated in all patients with HBsAg >20?000?IU/ml at week 24, whatever the HBV genotype [42]. Thus, on-treatment qHBsAg is useful not only to identify patients who are not likely to benefit from IFN as early as possible but also as a guide to the optimal treatment duration [43]. In addition to qHBsAg, a decline in qHBeAg has also been reported as a predictor of antiviral therapy [26]. In patients treated with 48?weeks of PEG-IFN, Fried et?al. reported that more than half of the patients with a qHBeAg level