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Interim PET was interpreted using SUVmax reduction between PET0 and PET2 (��SUV). Pts with a ��SUV >71% were good responders. Median follow-up was 47?months (6�C71). Results: Median MTV0 was 120 cc (10�C1610) and 17 pts (29%) had an MTV0 >225 cc. MTV0 (��225 vs >225) and tumour bulk were predictive of 4-year progression-free survival (PFS): 85% vs 42%; p?=?0.001 and 44% vs 79%, p?71 vs ��71%) had also an impact on patient's outcome (p? http://www.selleckchem.com/products/epz-5676.html analysis, using the international prognosis score, ��SUV, MTV0 and bulky tumour as covariates, only ��SUV and MTV0 remained independent predictors for PFS (p?=?0.0005; RR?=?6.3, and p?71 and MTV0 ��225 (n?=?37; 63%), or ��SUV 225 (n?=?17; 29%), or ��SUV 225 (n?=?5; 8%), had a 92%, 49%, and 20% 4-year PFS (p? http://www.selleckchem.com/products/ly2109761.html AFTER FIRST-LINE TREATMENT PREDICTS PROGRESSION-FREE AND OVERALL SURVIVAL IN PATIENTS WITH FOLLICULAR LYMPHOMA E. Gainza,1 G. Gutierrez Garcia,1 X. Setoain,2 B. Sanchez-Gonzalez,3 S. Rodriguez,4 A. Rodriguez-Trillos,1 C. Trempat,5 M. Villamor,1 A. Gaya,1 L. Colomo,1 A. Martinez-Pozo,6 E. Gine,1 J. Maiques,7 M. Garcia,8 S. Fuentes,2 E. Campo,6 A. Salar,3 A. Lopez-Guillermo.1 1Hematology, Hospital Clinic, Barcelona, Spain; 2Nuclear Medicine, Hospital Clinic, Barcelona, Spain; 3Hematology, Hospital Del Mar, Barcelona, Spain; 4Radiology, Hospital Clinic, Barcelona, Spain; 5Nuclear Medicine, Hospital Del Mar, Barcelona, Spain; 6Pathology, Hospital Clinic, Barcelona, Spain; 7Radiology, Hospital Del Mar, Barcelona, Spain; 8Pathology, Hospital Del Mar, Barcelona, Spain. Background: Follicular lymphoma (FL) is characterized by a relative long survival, with a pattern of continuous relapses. Achievement of complete response is an important issue for the outcome of the patients. The role of PET-CT, well established http://www.selleck.cn/products/Staurosporine.html in aggressive lymphomas, is not completely elucidated in FL. The purpose of this study was to assess the usefulness of PET-CT in the evaluation of response of patients with FL. Patients and Methods: One hundred sixteen patients (62M/54F; median age 59?years) with histologically proven FL (grades 1, 2, 3a 91; grade 3b, 9; not determined 16) underwent 18F-FDG PET-CT at diagnosis in all cases and after treatment (immunochemotherapy in the vast majority) in 90. FDG uptake was determined by standardized uptake value (SUV). Results: Initial PET-CT showed FDG uptake in 100% of assessable patients, with a median SUV of 6.