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Given that unique biological properties are unlikely to be associated with inadequate specimen handling or processing, we limited our subsequent analyses to patients only with inadequate banding or metaphases [n?=?94 (6%)] (Hereafter UC). Table?1 summarizes the baseline characteristics and cytogenetic classification of the cohorts. Patients with UC were older at diagnosis (median 60 vs. 54?years, P?=?0��08) and we noted an increased incidence with advancing age (P?=?0��08). No differences in treatment were observed between patients with accepted cytogenetic studies, UC and pre-analytical cohorts (P-value comparing the three cohorts?=?0��55) (data not shown). Next, we investigated the significance of UC on early treatment outcomes in patients with AML (Table?2). The https://www.selleck.cn/products/JNJ-26481585.html CR rate for UC patients (43%) was similar when compared to patients with unfavourable karyotype [excluding monosomal karyotype (MK+ AML)] (P?=?0��72), but significantly better than patients with MK+ AML (hereafter ��very unfavourable��) (P?=?0��04), and inferior to patients with favourable https://www.selleckchem.com/products/PD-0325901.html (P? https://www.selleckchem.com/products/epz-6438.html to patients with successful cytogenetic analysis (12% vs. 9%, P?=?0��47). Unadjusted and adjusted Cox analyses demonstrated a trend towards lower ED rate only when compared to MK+ AML (P?=?0��07 and P?=?0��06, respectively). Compared to patients with successful cytogenetic analysis, patients with UC had worse survival (HR?=?1��42 95% CI 1��29, 1��55), (P?=?0��002). As shown in Fig?1 and Table?2, survival was similar to patients with unfavourable risk cytogenetics (excluding MK+ AML). An unadjusted Cox model demonstrated that UC patients had worse OS compared to favourable or intermediate risk karyotype (P?