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The aim of this study was to evaluate laboratory data and the clinical outcome of fibrinogen administration in patients suffering from severe hemorrhage. Materials and methods: A retrospective study over a 3-year observation period of consecutive patients who received a single dose of fibrinogen concentrate but not recombinant factor VIIa as part of their treatment of severe hemorrhage, defined as >6?U of packed red blood cells (PRBCs). Results: Thirty-seven patients were included, most of http://www.selleckchem.com/products/Cisplatin.html them suffering from severe hemorrhage following open heart surgery (68%). After a median fibrinogen dose of 2?g (range 1�C6?g), an absolute increase in the plasma fibrinogen concentration of 0.6?g/l was observed (P http://www.selleck.cn/products/ve-821.html To evaluate the feasibility of determining the extent of sympathetic blockade by skin temperature measurement with infrared thermography and relate the cranial extent of the temperature increase to that of the sensory block after spinal anaesthesia. Methods: Before and 5, 10 and 20?min after the administration of spinal anaesthesia, skin temperatures were measured with infrared thermography at the dermatomes T2�CL3, http://www.selleckchem.com/products/Vorinostat-saha.html in 12 male patients scheduled for lower limb surgery. The most cephalad dermatome at which sensory blockade occurred was related to the dermatome at which the largest temperature jump (corrected for baseline temperature) occurred. Results: The baseline temperatures showed considerable variation across the dermatomes, being lower below T12 than at the thoracic dermatomes. The mean difference between the level of the cephalad skin temperature elevation front (mean 1.03?��C, SD 0.8?��C) and cranial sensory block height was 0.10 dermatomes (SD 1.16), correlation coefficient (0.88, P