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0), 20.8% (PSA 4.64?ng/mL), 58.5% (PV 32.6?cc) and 47.2% (PSAD 0.159), respectively. There was no significant difference in PCA3 score among subgroups (Gleason score of 6, 7 and 8 or more). Univariable logistic regression analysis showed age (P? http://www.selleckchem.com/products/midostaurin-pkc412.html predictors for prostate cancer in men with PSA less than 50?ng/mL, and that only PCA3 score (P? http://www.selleckchem.com/products/liproxstatin-1.html research assays.7�C14 We observed that the incidence of prostate cancer increased as the PCA3 score increased. A total of 69% of men with a PCA3 score of more than 50 had prostate cancer, whereas 5% of men with a PCA3 score of less than 20 had prostate cancer. No men with a PCA3 score less than 10 had prostate cancer. With the PCA3 cut-off of 10, 23 men would avoid the unnecessary biopsy. Thus, PCA3 score can be used to stratify the risk for a positive https://en.wikipedia.org/wiki/Ketanserin biopsy in men undergoing biopsy. Several studies have shown that the PCA3 assay has a high specificity for prostate cancer.8�C13 Using the APTIMA PCA3 assay, Groskopf et?al. reported that the sensitivity was 69% and the specificity of PCA3 assay was 79%, with a PCA3 score cut-off of 50 in North American men.10 Haese et?al. reported that the sensitivity was 47% and the specificity was 72%, with a PCA3 score cut-off of 35 in European men.12 Although the study population was small, we observed in Japanese men that the specificity was 85.1% and 74.6%, with a PCA3 score cut-off of 50 and 35, respectively. To our knowledge, this is the first study on assessing the diagnostic accuracy of PCA3 assay in Japanese men, and this result shows that specificity of PCA3 assay in Japan is comparable to that in the multiple reports in North America, as well as Europe, although the sensitivity varies in the different populations. Several studies have shown that PCA3 score is superior to serum PSA and free PSA in predicting prostate cancer in men undergoing prostate biopsy.11�C13 Using ROC analysis, Marks et?al.