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Representative staining images for negative, weak, and strong staining intensities, respectively, are depicted in Fig. 3c and Supporting Information Figure S1. Kaplan-Meier survival curves revealed significant differences between patients with strong CRYAB protein expression and those with no or weak expression in regard to OS and RFS (p = 0.044 and p = 0.043) (Fig. 3d). http://www.selleckchem.com/products/Bortezomib.html Significant differences in CRYAB mRNA levels (p http://www.selleckchem.com/products/gsk1120212-jtp-74057.html apoptotic cells as a function of increasing TRAIL concentrations with a median fraction of 43% apoptotic cells for OV-MZ-6 and 37% for HEY cells when stimulated with 15 ng TRAIL/ml (Fig. 4a, light grey boxes). Strikingly, in CRYAB-overexpressing cells (Fig. 4a, dark grey boxes), TRAIL-induced cellular apoptosis http://www.selleck.cn/products/bgj398-nvp-bgj398.html was significantly suppressed compared to vector transfectants (p